Résumé
Abstract Purpose: To evaluate the technical feasibility and homogeneity of drug distribution of pressurized intraperitoneal aerosol chemotherapy (PIPAC) based on a novel process of intraperitoneal drug application (multidirectional aerosolization). Methods: This was an in vivo experimental study in pigs. A single-port device was manufactured at the smallest diameter possible for multidirectional aerosolization of the chemotherapeutic drug under positive intraperitoneal pressure. Four domestic pigs were used in the study, one control animal that received multidirectional microjets of 9 mL/sec for 30 min and three animals that received multidirectional aerosolization (pig 02: 9 mL/sec for 30 min; pigs 03 and 04: 3 mL/sec for 15 min). Aerosolized silver nitrate solution was applied for anatomopathological evaluation of intraperitoneal drug distribution. Results: Injection time was able to maintain the pneumoperitoneum pressure below 20 mmHg. The rate of moderate silver nitrate staining was 45.4% for pig 01, 36.3% for pig 02, 36.3% for pig 03, and 72.7% for pig 04. Conclusions: Intra-abdominal drug distribution had a broad pattern, especially in animals exposed to the drug for 30 min. Our sample of only four animals was not large enough to demonstrate an association between aerosolization and a higher silver nitrate concentration in the stained abdominal regions.
Sujets)
Animaux , Tumeurs du péritoine/traitement médicamenteux , Systèmes de délivrance de médicaments/méthodes , Aérosols/administration et posologie , Tumeurs du péritoine/anatomopathologie , Tumeurs du péritoine/secondaire , Péritoine/effets des médicaments et des substances chimiques , Pression , Facteurs temps , Insufflation , Études de faisabilité , Systèmes de délivrance de médicaments/instrumentation , Aérosols/pharmacocinétique , Cavité abdominale , Sus scrofa , Modèles animaux de maladie humaine , Injections péritonealesRésumé
Com o objetivo de verificar a prevalência de fumantes entre estudantes universitários e a diferença entre os sexos, foi realizado um estudo transversal entre 450 alunos de todas as unidades acadêmicas da PUCRS...