[Management of non small cell lung cancer]

The broncopulmonary cancer is a major problem of public health whose diagnosis is most of the time unfavorable. For a long time, strategies of management of cancer have not taken into consideration much the histological type and few authors have studied the implication of histological type of cancer on the future of patients having cancer. Taking into account the results of recent studies, we propose to review the recent epidemiological and biological aspects of bronchial cancers and then to study the impact on the therapeutic strategy. Review of literature. The scientific progress and the discovery of new mechanisms of carcinogenesis considerably enlarge the therapeutic potential targets and enable to adopt a more specific approach of the cancer cell. Despite the progress observed in thoracic cancerology, the benefits concerning survival remain modest. The oncoming of new molecules specifically targeting a stage of oncogenesis enables a better therapeutic selectivity and a lesser toxicity

[Exercise induced anaphylaxis]

Exercise-induced anaphylaxis [EIA] is a rare physical allergy, sometimes severe, triggered by exertion following specific food intake. Although described several years ago, this condition is not well known; the diagnosis is frequently made several years after follow up. The aim is to describe the physiopathologic mechanism, etiologic factors, clinical manifestations and diagnostic means. Review of the literature. It is likely that exercise induce the release of a sufficient amount of mediators from mast IgE dependant cells exceeding a certain threshold. A number of food trigger have been suggested in EIA, the most commonly reported agent is wheat which has to be systematically looked for. A range of physical activities have been associated with EIA. Intensive physical activities are more likely to provoke an attack than less strenuous ones. The recognition of specific food causative role do not indicate the avoidance of food intake but exercise is forbidden within the four hours following specific aliment ingestion. Further studies seem to be necessary to clarify the mechanism of food dependent exercise-induced anaphylaxis