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Braz. j. med. biol. res ; 44(4): 276-282, Apr. 2011. ilus, tab
Article Dans Anglais | LILACS | ID: lil-581490

Résumé

The signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM-associated protein (SAP). SLAM is constitutively expressed in most of these cells, is rapidly induced after antigenic or inflammatory stimuli, and participates in the immunological synapse. Defects in the function of the SLAM-SAP pathway contribute to immunological abnormalities, resulting in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents. Initially, the role of SLAM was investigated using an anti-SLAM monoclonal antibody (α-SLAM mAb) identified as an agonist of the SLAM-SAP pathway, which could induce the production of interferon-γ and could redirect the immune response to a T helper 1 (Th1) cell profile. However, in this review we postulate that the SLAM-SAP pathway primarily induces a Th2 response and secondarily suppresses the Th1 response.


Sujets)
Humains , Antigènes CD/physiologie , /métabolisme , Protéines et peptides de signalisation intracellulaire/physiologie , Activation des lymphocytes , Récepteurs de surface cellulaire/physiologie , Transduction du signal/physiologie , Anticorps monoclonaux , Lymphocytes auxiliaires Th1/immunologie , Lymphocytes auxiliaires Th1/métabolisme , /immunologie , /métabolisme
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