1.
Indian J Exp Biol
;
1994 Aug; 32(8): 562-4
Article
Dans Anglais
| IMSEAR
| ID: sea-58259
Résumé
Cyclophosphamide induced a depletion in liver glutathione (GSH) and high rate of lipid peroxidation. GSH depletion was evident from 20 min onwards and the maximum depletion was observed at 3 hr post treatment. Lipid peroxidation was significant only after the maximum depletion of GSH. Pretreatment with either MPG or WR-77913 individually, or in combination could prevent the depletion of GSH and induction of lipid peroxidation after cyclophosphamide treatment.
Sujets)
Amifostine/analogues et dérivés , Animaux , Cyclophosphamide/antagonistes et inhibiteurs , Femelle , Glutathion/métabolisme , Peroxydation lipidique/effets des médicaments et des substances chimiques , Mâle , Souris , Tiopronine/pharmacologie
2.
Article
Dans Anglais
| IMSEAR
| ID: sea-123901