Résumé
Based on the kinetics of alcohol metabolism in animal models,the mathematicalmode for studing of the alcohol kinetics in person of the acute alcohol poisoningwas established.This mathematical mode can be expressed as x(t)=x_0(1-e~(-kat))-k_bt,which allows calculating the absorpion constant (k_a) arld breakdown rate constant(k_b) for alcohol the curve in dynamic change of the alcohol concentration followingadministration of a large amount of alcohal can be obtained the amount of alcoholin human body [x,(t)] after drinking can be checked out.from the urine Theexperimental study in monkeys showed that the parameters derived from the mathe-matical mode agued witk the results obtained from the experiments
Résumé
Sixteen normal male volunteers were randomly divided into two groups and were asked to drink two doses of ethanol 0. 65g/kg and 0. 80g/kg alcoholic beverage seperately. Then the venous blood sample was collected at the different time. A ADH enzyme catalyzed method was used to determine the blood alcohol concentration (BAC). The experimental concentration-time (C-T) data was calcu-lated by the pharmacokinetics software,the result showed that the metabolism of alcohol confirmed with 1 -compartment nonlinear pharmacokinetics with first absorption model. According to this, a mathematic formula of alcoholic dynamics in human body was established. After the test of human ex-periment, the model was found suitable in the practice of forensic medicine.
Résumé
A high performance liquid chromatography (HPLC)has been used to determine aconitine in the sample of rabbits. Kinetics of degradation of aconitine in vitro was studied. The degradation of aconite from the poisoned specimens (coagulated blood, liver) treated differently in vitro was characterized by pseudo-secondorder kinetics. The K. of aconitine in these samples was the biggest in the fixed section of 4% aqueous solution of formaldehyde (1.5619, O.7728?g/d), bigger in the fixed section of 95% alcohol(0.4891, 0.07536?g/d) and the smallest in the refrigerator at 4℃ (0.06372, 0.03903 ?g/d), respectively. That is, aconitine in the poisoned samples was decomposed slowly in the refrigerator and secondly in the fixative of alcohol. Amount of aconitine might be extrapolated from the result of examination of specimens taken from the subject after poisoning or killing by the poison, using the kinetics equation.