Experiment Study of the New Method for Treating Injury Caused by Extravasation of Vincrisine / 中国药房

OBJECTIVE:To observe the effect of2%anisodamine plus1%lidocaine block therapy on injury caused by extravasation of vincrisine.METHODS:60animal models were established by injecting1%vincrisine5ml into ear vein with1ml purposely extravasating to subcutaneous tissue in rabbits.The rabbits were divided randomly into groupⅠ,groupⅡand control group.GroupⅠreceived2%anisodamine+1%lidocaine,groupⅡ2%anisodamine and control group normal saline.RESULTS:After2weeks treatment,the total effective and curative rate in three groups were90%and80%,63%and42%,15%and0%respectively.CONCLUSION:2%anisodamine plus1%lidocaine block therapy is superior to normal saline in treating extravasation injury of vincrisine.