Behavior research of allergic rhinitis with adenoid hypertrophy in children / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the behavior difference of allergic rhinitis with adenoid hypertrophy between study group and control group.@*METHOD@#One hundred and seventeen children diagnosed as allergic rhinitis with adenoid hypertrophy were enrolled in our study were divided into study group and control group. Forty-two children treated with local steroid nasal spray for two to three months and antihistamine were control group. Seventy-five children treated with endoscopic adenoidectomy and drug treatment were study group; All children' parents were inquired for their clinical presentation.@*RESULT@#No distinctive differences were found between the two groups (P > 0.05) in adenoid hypertrophy, accompanying nasal problems and clinical questionnaire scoring. Significant statistical distinction were found (P < 0.05) in snoring, sleep disturbance and frequent arousal, nasal obstructive moth-breathing, and recurrent respiratory tract infection between the two groups after three-month follow up.@*CONCLUSION@#Endoscopic adenoidectomy should be taken into account for allergic rhinitis with adenoid hypertrophy in children. Adenoidectomy would be useful for the improvement of behavior symptoms.

Studies on the effects of Qi-boosting toxin-resolving decoction on proliferation of nasopharyngeal carcinoma cell / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the effect of several traditional Chinese medicine formula therapies on proliferation of nasopharyngeal carcinoma cell line HNE1.@*METHOD@#The inhibition effect of medicine serums of Qi-Boosting Toxin-Resolving granule on proliferation of NPC cell line HNE1 in vitro was observed by MTT assay.@*RESULT@#The rates of survival cells in Qi-Boosting Toxin-Resolving decoction group and Toxin-Resolving group were the lowest after 48 hours treatment, while Qi-Boosting group, yin-nourishing group, residual-component group medicine serums had the most obvious effects on the rates of survival cells at 72 hours. The inhibition ratio of 15% Qi-Boosting Toxin-Resolving granule medicine serums was 67.68%.@*CONCLUSION@#The result of MTT assay showed that cell proliferation was significantly inhibited by Qi-Boosting Toxin-Resolving granule and its separate composes medicine serums. Qi-Boosting Toxin-Resolving granule had the most significantly specific effects. The effects were correlated with serum concentration and treatment time of Qi-Boosting Toxin-Resolving granule and its separate composes medicine.

Round window catheter placement with dexamethasone perfusion for intractable sudden sensorineural hearing loss / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the efficacy of round window catheter placement with dexamethasone perfusion for 13 patients with intractable sudden sensorineural hearing loss (SSNHL).@*METHOD@#Dexamethasone (2.5 mg) was perfused transtympanically through round window catheter by Micro-infusion pump. The perfusion was taken twice a day and continued for an hour each time, for a total of 7 days.@*RESULT@#Thirteen patients have been followed up for 1 month. Five of them (38.5%) were demonstrated a 17-54 dB improvement in pure-tone threshold average (PTA). The other 8 patients (61.5%) had no effect.@*CONCLUSION@#Round window catheter placement with dexamethasone perfusion is a cost-effective and useful treatment for SSNHL patients who had no effect through conventional therapy, although hearing thresholds of these patients had hardly improved to normal levels.