Serum gastrin, pepsinogens, parietal cell and Helicobacter pylori antibodies in patients with gastric polyps

OBJECTIVES: To determine serum concentration of gastrin and pepsinogens (PGs) as markers for the gastric mucosal status and to elucidate the prevalence of serum Helicobacter pylori (H pylori) IgG antibodies and parietal cell autoantibodies (PCAs) in patients with gastric polyps. METHODS: The subjects in this study were composed of 36 patients with fundic glandular polyps (FGP), 25 patients with foveolar hyperplastic polyps (FHP), and 27 asymptomatic healthy volunteers (controls). Serum concentrations of gastrin and PGs were determined by radioinmmunoassay. H. pylori IgG antibodies were measured through an enzyme-linked immunosorbent assay. PCAs were detected by an indirect immunofluorescence technique using cryostat sections of rat gastric mucosa. RESULTS: There were no significant differences between FGP patients and controls in serum concentrations of gastrin, PG I and PG II. FHP patients showed significantly higher serum gastrin, lower PG I, higher PG II levels and, as a consequence, far lower PG I/PG II ratio compared with controls. The prevalence of H pylori infection was much higher in FHP patients (84.0

), whereas lower in FGP patients (19.44

) than that in controls (40.7

) was positive in 24.0

of FGP patients and 4

of controls. CONCLUSIONS: These results suggest that FHP often develops in a gastric mucosa associated with H pylori infection, while FGP does not appear to be related to H pylori infection.

Campylobacter pilórico, gastritis crónica, úlcera gástrica y úlcera duodenal / Pyloric campylobacter, chronic gastritis, gastric ulcer and duodenal ulcer

Diversos trabajos demuestram un elevado porcentaje de hallazgo del campylobacter pilórico en casos de gastritis crónica y úlcera péptica. Presentamos nuestra experiencia en 672 pacientes evaluados mediante esofagogastroduodenoscopía, por presentar síntomas del tracto gastrointestinal superior. Se utilizó el Panendoscopio Olympus GIF-k2 tomándose dos biopsias del antro gástrico. Los especimenes fueron sometidos a coloración con hematoxilinaeosina y con plata, métodos que nos han dado los mejores resultados diagnósticos. El diagnóstico de úlcera gástrica o duodenal se hizo sobre la base del hallazgo endoscópico y para el diagnóstico de gastritis crônica se consideró el criterio histológico. La gastritis se ha dividido en activa e inactica. Se ha cuantificado el daño mucinoso y el grado colonización bacteriana. Hemos encontrado a la bacteria en el 91.8% de pacientes con gastritis crónica activa, 72.7% con úlcera gástrica y 84.2% con úlcera duodenal. Nuestros resultados sosn concordantes con los de otros autores. Concluimos que el campylobacter pilórico no es un germen oportunista en el estómago, pues produce cuadro inflamatorio y daño celular mucinoso. Su presencia puede jugar algún rol en la etiopatogenia de la úlcera péptica y gastritis