Résumé
Acute generalized intravascular coagulation is regularly associated with fibrinolysis. Evidence of the clotting process includes thrombocytopenia, hypofibrinogenemia, prolongation of the prothrombin time (deficiency of factor V and fibrinogen) and of the partial thromboplastin time (factor VIII is also deficient). Evidence of fibrinolysis is elevation of fibrinolytic split products (FSP or FDP). A positive protamine gel results from both coagulation and fibrinolysis.
Sujets)
Facteurs de la coagulation sanguine/métabolisme , Coagulation intravasculaire disséminée/sang , Fibrine/métabolisme , Produits de dégradation de la fibrine et du fibrinogène/métabolisme , Fibrinolyse , Humains , Dosage radioimmunologique , Thrombine/métabolismeRésumé
Primary diseases of platelet function include Glanzmann's thrombasthenia, hereditary platelet release abnormalities (storage pool disease and release defect), Bernard-Soulier giant platelet syndrome, and platelet factor 3 defects. Qualitative defects of platelets are associated with many diseases, notably of the liver and kidney, and with the use of many drugs, particularly aspirin.