Nocturnal enuresis, a new side effect of valproate in adult: A case report.

Valproate is anticonvulsant which has been used in treatment and prevention of bipolar disorders. Its common side effects are nausea, tremor, weight gain. Other less common side effects are sedation, hair loss, thrombocytopenia, hepatotoxicity. There were several studies of valproate in children treated for seizures recording enuresis as a side effect. As far as we know, this unwanted side effect has not been previously reported in adult patients nor in bipolar disorder patients. So we report here a case of 45-year-old man with rapid cycling bipolar disorder, whose symptoms responded well to valproate, developed enuresis as a side-effect of valproate.