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1.
Chinese Journal of Oncology ; (12): 629-631, 2007.
Article Dans Chinois | WPRIM | ID: wpr-298532

Résumé

<p><b>OBJECTIVE</b>The purpose of this study was to investigate the clinical characteristics of lymph node metastasis in the contralateral mediastinum and scalene in patients with potentially operable nonsmall cell lung cancer (NSCLC).</p><p><b>METHODS</b>Cervical mediastinoscopy was performed for 89 patients with clinical stage I-III A non-small cell lung cancer prior to thoracotomy. Of these, 12 underwent cervical medistinoscopy combined with right scalene lymph node biopsy and 10 with anterior para-mediastinal small incision.</p><p><b>RESULTS</b>A total of 9 patients were found have N3 disease on mediastinosopy, with cancer-cell-positive lymph nodes in the contralateral mediastinum in 6 and 3 in the right scalene. Statistical analysis revealed that the incidence of N3 disease in adenocarcinoma group was higher than that in patients with nonadenocarcinoma (P < 0.05), which was also higher in the patients with serum CEA >5 ng/ml than that in the patients with CEA <5 ng/ml (P < 0.05), and it was higher in the patients with ipsilateral mediastinal multi-station lymph node metastasis than that in the patients with uni-station lymph node metastasis (P < 0.05).</p><p><b>CONCLUSION</b>Biopsy of contralateral mediastinal lymph nodes or scalene lymph node should be performed in order to exclude N3 disease for potentially operable NSCLC patients with adenocarcinoma, serum CEA >5 ng/ml or ipsilateral multi-station mediastinal lymph node metastasis.</p>


Sujets)
Adulte , Sujet âgé , Femelle , Humains , Mâle , Adulte d'âge moyen , Adénocarcinome , Sang , Anatomopathologie , Thérapeutique , Biopsie , Antigène carcinoembryonnaire , Sang , Carcinome pulmonaire non à petites cellules , Sang , Anatomopathologie , Thérapeutique , Carcinome épidermoïde , Sang , Anatomopathologie , Thérapeutique , Traitement médicamenteux adjuvant , Tumeurs du poumon , Sang , Anatomopathologie , Thérapeutique , Lymphadénectomie , Noeuds lymphatiques , Anatomopathologie , Métastase lymphatique , Médiastinoscopie , Médiastin , Muscles du cou , Stadification tumorale , Pneumonectomie
2.
Chinese Journal of Oncology ; (12): 472-474, 2003.
Article Dans Chinois | WPRIM | ID: wpr-347399

Résumé

<p><b>OBJECTIVE</b>To study the optimal surgical resection length for esophageal carcinoma.</p><p><b>METHODS</b>Specimens of seventy patients with esophageal squamous cell carcinoma resected and collected in our hospital were made into pathologic giant sections. Direct intramural infiltration, multicentric carcinogenic lesion and leaping metastasis were observed in the large slice by microscope. The actual length during the operation was calculated by the ratio of shrinkage.</p><p><b>RESULTS</b>Direct intramural infiltration was found in 51 (72.9%) patients, 39 proximal and 36 distal to the tumor. The mean length of direct intramural infiltration was 0.9 +/- 0.8 cm (4.0 cm maximum) proximally and 0.5 +/- 0.3 cm (2.0 cm maximum) distally. Multicentric carcinogenic lesion was found in 11 (15.7%) patients, 5 proximally, 8 distally and 2 on both sides. Proximal to the tumor, the mean distance between the multicentric carcinogenic lesion and the main lesion plus the length of the multiple carcinogenic lesion was 3.2 +/- 1.5 cm (4.7 cm maximum). Distal to the tumor, it was 3.6 +/- 2.4 cm (9.1 cm maximum). Leaping metastasis was found in 9 (12.9%) patients, 7 proximally and 4 distally. The mean distance between the leaping metastasis and the main lesion plus the length of the leaping metastatic lesion was 1.9 +/- 0.6 cm (2.9 cm maximum) proximally and 1.4 +/- 1.0 cm (2.7 cm in maximum) distally.</p><p><b>CONCLUSION</b>The optimal surgical resection length for esophageal carcinoma should be at least 5 cm proximal to the tumor and total length on the distal side.</p>


Sujets)
Femelle , Humains , Mâle , Tumeurs de l'oesophage , Anatomopathologie , Chirurgie générale , Invasion tumorale
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