In vitro susceptibility to antifungal agents of clinical and environmental Cryptococcus neoformans isolated in Southern of Brazil

The purpose of the present study was to compare the susceptibility to four antifungal agents of 69 Cryptococcus neoformans strains isolated from AIDS patients with that of 13 C. neoformans strains isolated from the environment. Based on the NCCLS M27-A methodology the Minimal Inhibitory Concentrations (MICs) obtained for amphotericin B, itraconazole and ketoconazole were very similar for clinical and environmental isolates. Clinical isolates were less susceptible to fluconazole than environmental isolates. The significance of these findings and aspects concerning the importance, role and difficulties of C. neoformans susceptibility testing are also discussed

Case of mycotic keratis caused by Fusarium solani

O caso estudado refere-se a paciente de sexo masculino, 36 anos, feoderma, sem historia de doenca sistemica ou trauma ocular, apresentando ulcera corneana no olho esquerdo. Antes do estabelecimento do diagnostico especifico, o paciente foi tratado com antibiotico associado a corticosteroides durante um mes...