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1.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;21(4): 851-3, 1988. ilus, tab
Article de Anglais | LILACS | ID: lil-60809

RÉSUMÉ

A single dose of calcitonin (150 mIU/100g body weight, sc) produced a significant decrease in liver antipyrine hydroxylase and aminopyrine demethylase activities. By contrast, pentobarbital sleeping time was not altered by calcitonin treatment. The present results indicate that acute calcitonin administration depresses the metabolism of substrates of the mixed function oxidase system of rat liver


Sujet(s)
Rats , Animaux , Mâle , Calcitonine/pharmacologie , Foie/enzymologie , Mixed function oxygenases/métabolisme , Sommeil/effets des médicaments et des substances chimiques , Cytochrome P-450 enzyme system , Microsomes du foie
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