Investigation of Corchorus olitorius mucilage as a potential mucoadhesive agent in developing in situ mucoadhesive nasal gel

The present study aimed to formulate a mucoadhesive in situ gel with mucilage extracted from Corchorus olitoriusfor the intranasal route. Propranolol HCl used as a model drug. For the comparative study, the mucoadhesive in situgels were prepared using two different concentration 0.4% and 0.5% of C. olitorius mucilage, Carbopol P-934 andhydroxypropyl methylcellulose. The prepared in situ gel was subjected to characterization test, such as pH, appearance,gelation temperature, spreadability, viscosity, mucoadhesive strength, and in vitro study. From the comparative study,0.5% mucilage containing in situ gel formulation can be considered as optimum formulation.

Natural Indicator as a substitute to Synthetic indicator-A Developmental Approach.

Synthetic indicators had perpetually been an alternative choice for all types of titration since long time. However price had always been a tangle. Therefore development of an indicator from natural source i.e. from the flower extracts had been the main aim of this present research work. The current work complies data regarding the comparison of Natural indicator and synthetic indicator and whether or not it may be substituted from Synthetic indicator.