Sujets)
Implantation embryonnaire/effets des médicaments et des substances chimiques , Transfert d'embryon/méthodes , Femelle , Fécondation in vitro/tendances , Thérapie génétique/tendances , Hormone de libération des gonadotrophines/antagonistes et inhibiteurs , Humains , Mâle , Induction d'ovulation/méthodes , Médecine de la reproduction/tendances , Techniques de reproduction/tendances , Maturation du spermatozoïde/physiologieRésumé
Couples (225) found negative for clinical, hormonal and biochemical problems as causes of recurrent abortion were studied for cytogenetic abnormalities. Nineteen per cent of the 450 individuals exhibited chromosomal anomalies. Eighty one per cent of the anomalies were structural, 18% numerical and 47% mosaics, the last being unexpectedly high. Forty seven per cent of the cases with anomalies carried translocations but in 21% of the cases, satellite association between D and G groups indicated an important role of satellite association in recurrent abortion and congenital defects. Some cases with even 10% of abnormal metaphases suffered recurrent abortion. Genetic diagnosis and counseling are, therefore, strongly advised in recurrent abortion.