Résumé
Objective@#To compare the clinical effect of metoprolol combined with valsartan and nifedipine controlled release tablets in the treatment of primary hypertension complicated with coronary heart disease(CHD).@*Methods@#200 primary hypertension patients with CHD were selected, and they were randomly divided into observation group and control group according to the digital table, 100 cases in each group.The observation group was treated with metoprolol combined with valsartan, the control group was treated with nifedipine controlled release tablets.The clinical effect of the two groups was compared.@*Results@#Before treatment, the diastolic and systolic blood pressure of the control group were (106.8±12.3)mmHg and (173.4±22.8)mmHg, respectively, which of the observation group were (104.3±11.4)mmHg, (177.6±24.2)mmHg, respectively, the differences were not statistically significant between the two groups(t=1.265, 0.337, all P>0.05). The diastolic and systolic blood pressure after treatmentin of the observation group were (131.6±17.4)mmHg, (85.3±7.1)mmHg, respectively, and the total effective rate of the observation group was 93.0%(93/100), the improvement rate of angina symptoms of the observation group was 86.0%(86/100), which were significantly better than those of the control group[(131.6±17.4)mmHg, (85.3±7.1) mmHg, 68.0%(68/100), 63.0%(63/100)], the differences were statistically significant (t=5.229, 6.122, χ2=9.148, 7.224, all P<0.05).@*Conclusion@#The combination of metoprolol and valsartan has better effect in the treatment of primary hypertension complicated with CHD compared with nifedipine controlled release tablets.
Résumé
Objective To explore the effect of amiodarone combined with carvedilol in the treatment of patients with arrhythmia.Methods 90 patients with cardiac arrhythmia were selected .According to different treatment,the patients were divided into control group and observation group ,45 cases in each group.The control group was treated with amiodarone , the observation group was given amiodarone combined with carvedilol .The therapeutic effect of the two groups was observed .Results Before treatment , the systolic blood pressure [ ( 149 ± 11)mmHg vs.(151 ±14) mmHg)],diastolic blood pressure [(95 ±11) mmHg vs.(95 ±12) mmHg)],heart rate [(143 ±16)times/min vs.(141 ±18)times/min] between the two groups had no statistically significant differences (t =6.214, 1.907, 3.228, all P >0.05 ).After treatment, the effective rate ( 91.11％), cardioversion rate (88.89％),standard time to achieve effective treatment [(2.50 ±0.79) d],systolic blood pressure [(119 ± 12)mmHg],diastolic blood pressure[(78 ±12)mmHg],heart rate [(78 ±20)times/min] in the observation group were better than those in the control group [86.67％,75.56％,(5.62 ±3.16) d,(142 ±15) mmHg,(90 ± 13)mmHg,(99 ±23) times/min],and the differences between the two groups were statistically significant (χ2 =8.235,7.157,t =6.214,5.718,5.102,all P<0.05).Conclusion Carvedilol combined with amiodarone in the treatment of patients with abnormal heart rate can significantly improve the cardiac function ,suppress deterioration , and can be widely used in clinical treatment .
Résumé
Objective To explore the possible effects of nutritional supplements on brain function as reflected by Water Maze test performance in mice after +Gz exposure.Method Mice were arranged into control group (group A),+Gz group without nutritional supplementation (group B) and +Gz plus nutritional supplementation group (group C).Each group contains 12 mice.Mice in group A were not exposed to +Gz while mice in both group B and group C were exposed to 8 min +10 Gz.Distilled water was gavaged to group B mice 3 h before +Gz exposure.On the day before +Gz exposure pyridoxol fortified water was given and 3 h before exposure mixed amino acids solution were gavaged to group C mice.Water Maze test was done and scores were recorded in all groups.After the Water Maze test was completed,blood was collected through the eyes for serum amino acid determinations and brain tissue was collected by decollation for monoamine determination and γ-glutamyl transferase (GGT) activity evaluation. Result After +Gz exposure,longer completion time and more mistakes were observed in Water Maze test in group B as compared with group A and a trend of improvement in group C was noticed. The ratio of brain 5-HT to dopamine(DA) was significantly reduced in group C as compared with group B.Gamma glutamyl transferase (GGT) activity in brain tissue in group C and group B increased significantly. Conclusion High sustained +Gz exposure significantly reduces Water Maze test performance in mice (longer completion time and more mistakes).It seems that there is a trend of improvement in Water Maze performance in mice in dietary nutritional supplementation group,which might be due to significant reduction in ratio of brain 5-HT to DA in mice with nutritional supplementation.
Résumé
To evaluate the effect of vitamin E on GPT, GOT and LDH activity of cold exposed rats, young male rats (70-100g body weight) were randomly divided into Ⅰ-Ⅲ groups. All the animals were fed on basic ration. The group I was given vitamin E 5mg (5mg/ml) intraperitoneally once every other day for 10 days. After the vitamin E treatment, group Ⅰ and Ⅲ were kept in a cold chamber (-1?1℃) and group Ⅱ at room temperature (20?1℃) for 48 hours. At the end of experimental period, serum GPT, GOT and LDH activity of all animals were analyzed. According to the data, the GPT, GOT and LDH activity were increased significantly in group I than in groups Ⅰ and Ⅱ. These results suggested that the vitamin E may have the efficiency of maintaining the structural integrity of the cells of cold exposed animals.
Résumé
To evaluate the effect of Vitamin E on mitoc bond rial function of cold exposed rats male weaning rats were divided randomly into three groups. The group A was supplemented with 30 mg ?-tocopherol and 15?g sodium selenite per 100gm basal diet. The group B and C were fed basal diet on- ly. The group A and B were kept at the cold room (-2?1℃) and the group C kept at room temperature. Liver mitochondria were isolated for measurement of its respiratory function. Succinate was utilized as substrates of oxidative phosphorylation. Respiration rates of state 3 oxygen uptake and therefore ATP synthesis were found to increase with Vitamin E supplemented diet. Significantly less decline of ADP/O ratios and RCR was observed for group A than that of group B. These results suggest that Vitamin E has the effect of maintaining the physiological intactness of mitochondria of the cold exposed rats, and therefore may enhance the metabolic conservation of energy with the consequence of increasing the ability of cold tolerance of the cold exposed animals.
Résumé
Blood glucose level responses to different diets were examined in 12 healthy man. The test breakfasts consist of different proportion of protein and carbohydrate. Three kinds of test breakfast were fed respectively for each person. Blood glucose were measured before and 1, 2 and 4 hr after breakfast. The results indicated that high-CHO diet maintained higher level of blood glucose than other diets in 1-2 hr after breakfast. However the blood glucose level began dropping from 2 hr and dropped below fasting level at 4 hr after breakfast. The high-protein diet resulted in decreasing of blood glucose level in 1-2 hr after breakfast. The blood glucose level then increased continuously until 4 hr after breakfast.The results in this experiment showed that adjustment of the proportion of carbohydrate and protein in diets could maintain the blood glucose to a higher and stable level.