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Aims: The area and production of pigeon pea in Bhadohi are still significantly lower than in other districts of other states. There is a significant yield gap between the potential output and the yield under current farming conditions. To study the impact of technological interventions on the pigeon pea crop for increasing income through Cluster Front Line Demonstrations was the goal of the current study.Place and Duration of Study: Cluster front line demonstrations on improved pigeon pea technologies were carried out by ICAR-IIVR-Krishi Vigyan Kendra, Bhadohi, at farmers' fields from 2015–16 to 2019–20.Methodology: A total of 155 pigeon pea cluster front line demonstrations on improved pigeon pea technologies covering a 45.70 hectare area were held in one hundred eighteen localities. Field days, training and group meetings were also organized to provide opportunities for other farmers to witness the benefits of demonstrated technologies. The output data were collected from CFLD plots as well as control plots (farmers practice) by random crop cutting method and analyzed using simple statistical tools such as per cent change in yield, cost of cultivation, net income, and benefit cost ratio etc. Results: In the experimental plots, the mean yield over five years was 15.44 q/ha, while it was only 11.21 q/ha in the control plots. Over the course of the five years of the study, the yield development varied, though on average, it was measured at 42.49 percent. When compared to the farmer's practice (28,463/ha), the average net return for the demonstration plots at the farmer's field over the investigation period was greater at 56,611/ha. Additionally, the demonstration plots' benefit-cost ratio was larger (2.32) than the farmer's practice's (1.69).Conclusion: From the aforementioned findings, it can be concluded that using modern technologies for pigeon pea cultivation may significantly close the extension and technology gap, increasing pigeon pea yield in the area. It requires collaborative extension efforts to enhance the adoption of location and crop specific technologies among the farmers to bridge these gaps.
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Aims: Tomatoes benefit local farmers because of their excellent storage and truck-gardening capabilities. Because of local demand, tomatoes are a prominent commercial vegetable production in the Bhadohi area. A Frontline demonstration was held to cover the aforementioned possibility and impact of increase farmer earnings.Place and Duration of Study: The current study was conducted by ICAR-IIVR - Krishi Vigyan Kendra, Bhadohi for five years in a row from 2018–19 to 2022–23 in the farmers' fields in various areas of the district using front-line demonstration.Methodology: Over the investigation's five years, a total of 112 demonstrations were held at farmer fields on 5.0 ha of land. Each frontline demonstration was set up on 0.1 ha of land, with the nearby 0.3 ha serving as the comparison control (farmer's practice). KVK scientists gathered information on yield, production costs, and returns from farmers' practice plots (control plots) and front-line demonstration plots. Finally, the formulas proposed by Samui et al. [1] was used to calculate the extension gap, technology gap, and technology index.Results: Under the five-year FLD program, the average extension gap was 140.9 q/ha, the technology gap was 184.74 q/ha, and the technology indexwas 30.79 percent. The benefit cost ratio of tomato ranged from 5.02 to 7.44 in demonstration plots and from 3.99 to 5.74 in farmer’s practice plots during five years of demonstration with an average of 2.60 in demonstration and 2.09 under farmer’s practices. Conclusion: Front-line example shows how new technology may boost output and profit .The Bhadohi districts of Uttar Pradesh's mid plain have improved vegetable production, consumption, nutritional security, and overall livelihood security as a result of the productivity gain under FLD over existing tomato cultivation practices. This has increased awareness and inspired other farmers in the district to adopt the demonstrated technologies for tomato production.
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BACKGROUND: Nottingham prognostic index (NPI) is a widely used integrated prognostic variable in patients with breast cancer. NPI has been correlated with tumor size, grade, lymph node stage and patient survival. The present study aimed at evaluating and correlating the various clinical and pathologic features of breast carcinoma with NPI. METHODS: This study included 100 consecutive cases of primary breast carcinoma over a period of 2 years. Demographic data was noted and histomorphological features like tumor size, grade, lymph node involvement, necrosis, vascular invasion etc., were assessed. NPI was calculated as reported in the literature. Immunohistochemical staining for hormone receptors and CD34 (to calculate microvessel density [MVD]) was performed. Statistical analysis was used for correlation. RESULTS: Of the 100 cases, 54% of the tumors were in T2 tumor size category (2‑5 cm) and lymph node metastasis in 48% of the cases. NPI ranged from 2.3 to 7.3 with 54% of the cases in the intermediate NPI group (3.41‑5.4). The mean MVD was 160.93 (±69.4/mm2). On statistical analysis, tumor size and grade, lymph node stage, mitotic rate, nuclear pleomorphism, necrosis and MVD showed a correlation with NPI (P < 0.05). CONCLUSION: NPI is an important and useful prognostic indicator for breast cancer patients, which shows the correlation with other histomorphological prognostic features as well.
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Background: This study was undertaken to report the results of weekly combination chemotherapy with cetuximab in recurrent/metastatic head and neck squamous cell carcinoma (R/M SCCHN). Materials and Methods: Retrospective analysis of 35 R/M SCCHN patients who received cetuximab with weekly paclitaxel and platin (cisplatin/carboplatin) from SCCHN August 2006 to October 2008 at our Institute was performed. Results: Thirty-five patients (33 [94.3%] males and 2 [5.7%] females) received the planned weekly chemotherapy protocol. Median age of these patients was 52 years. Of the SCCHN 32 evaluable patients, 25 patients showed symptomatic improvement and 7 showed no improvement. Radiological responses using RECIST criteria reported CR in 1 patient (3.1%), PR in 17 patients (53.1%), and SD in 6 patients (18.8%). The remaining six patients demonstrated disease progression while two could not be assessed. Median overall survival (OS) was 8.016 months (95% CI; 6.572--9.461) and median PFS was 5.782 months (95% CI; 4.521--7.044). The major chemotherapy-related grades 2 and 3 toxicity recorded was cetuximab-induced rash reported in 24 patients. No treatment-related death within 30 days was observed. Conclusion: Cetuximab with weekly combination chemotherapy (Paclitaxel + Platinum compound) has shown promise, demonstrating comparable response and outcomes with acceptable toxicity in R/M SCCHN patients.
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The two sampling techniques were studied in 160 randomly selected cases of superficial swellings in various sites of the body. They were sampled by fine needle aspiration (FNA) and by non-aspiration (NA) (a needle without application of aspiration pressure). Cell samples were cytologically assessed and critically evaluated using five objective parameters. Contamination with blood was more in lymphnode, thyroid and liver lesions in aspiration smears than NA smears and values were statistically significant. Similarly when compared for the degree of cellular trauma and cellular degeneration statistically significant better results were obtained by nonaspiration technique for lymphnode lesions. Regarding amount of cellular material obtained by FNA, statistical significant better results were found for breast lesions only. Statistically significant better maintenance of architecture was observed only for thyroid lesions by NA technique. Better average scores were observed by NA technique for lymphnode and thyroid only. Categorizing all the smears obtained by FNA & NA on the basis of their scores according to predetermined criteria, greater number of diagnostically adequate specimens were obtained by FNA than by NA but the number of diagnostically superior specimens obtained by NA technique was found to be more than that by FNA. The difference was found to be statistically significant. However the number of inadequate smears was also more by NA technique than by FNA technique.