Résumé
Pegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. It has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin. It rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in many kinds of mucocutaneous reactions, including palmar-plantar erythrodysesthesia, diffuse follicular rash, intertrigo-like eruption, new formation of melanotic macules, stomatitis and radiation recall dermatitis. We present a rare case of multiple myeloma who immediately developed serious stomatitis and esophatitis associated with minor palmar-plantar erythrodysesthesia after a single course of pegylated liposomal doxorubicin.
.Sujets)
Sujet âgé , Femelle , Humains , Antibiotiques antinéoplasiques/effets indésirables , Doxorubicine/analogues et dérivés , Oesophagite/induit chimiquement , Syndrome mains-pieds/étiologie , Stomatite/induit chimiquement , Doxorubicine/effets indésirables , Oesophagite/anatomopathologie , Muqueuse gastrique/effets des médicaments et des substances chimiques , Syndrome mains-pieds/anatomopathologie , Muqueuse de la bouche/effets des médicaments et des substances chimiques , Myélome multiple/complications , Myélome multiple/traitement médicamenteux , Polyéthylène glycols/effets indésirables , Stomatite/anatomopathologieRésumé
Immunoglobulin light chain amyloidosis is the most common acquired systemic amyloidosis. Its presentation is often insidious and progressive, which may delay diagnosis. The authors describe a rare case of immunoglobulin light chain amyloidosis in a 34-year-old man with scleroderma-like manifestation substantiated by multifarious laboratory investigations and the histopathologic feature of involved skin lesions stained with Congo red and crystal violet. This helps to maintain a high clinical suspicion of the disease when confronting similar skin presentation.