Progress of DNA methylation and hydroxymethylation in breast cancer / 肿瘤研究与临床

Breast cancer is one of the most common malignant tumors in women and the second leading cause of death in female cancer patients. In recent years, the incidence of breast cancer has been increasing in China year by year, and the age of breast cancer patients becomes younger and younger. The pathogenesis of breast cancer is complex and related to many factors, such as age, family history and genetic variation. With the development of epigenetics, DNA modification plays an important role in the occurrence and development of breast cancer. This article reviews the research of DNA methylation and hydroxymethylation in breast cancer.

A new lignan from the hawk tea / 药学学报

The chemical constituents of Litsea coreana were investigated using chromatographic methods, including column chromatography on silica gel, MCI, and semi-preparation HPLC. Two compounds were isolated and identified as hawktealignan A (1) and cinnamophilin (2) by NMR analyses as well as their physical and chemical properties. Compound 1 is a new lignan and compound 2 was isolated from this plant for the first time.

Surgical techniques of pelvic autonomic nerves protection in laparoscopic total mesorectal excision for the treatment of rectal neoplasms / 中华消化外科杂志

Laparoscopic radical resection of rectal neoplasms is still under clinical research currently due to the following 2 reasons. Firstly, compared with open surgery, the longterm efficacy of laparoscopic surgery remains unclear; secondly, the pelvic autonomic nerves are difficult to be exposed and easy to be damaged during the surgery under laparoscope. Till present time, our department has completed 800 cases of laparoscopic radical resection of colorectal neoplasms, in which rectal neoplasms accounted for 70%. For most cases, the pelvic autonomic nerves have been exposed and protected properly. This paper summarized the skills to protect the pelvic autonomic nerves in the laparoscopic total mesorectal excision used for the treatment of rectal neoplasms.

Docetaxel-induced nail toxicity: a case of severe onycholysis and topic review / 中华医学杂志(英文版)

Docetaxel is a commonly-used anti-cancer chemotherapeutic agent given its efficacy in a large variety of solid tumors. It is associated with various adverse effects one of which is nail toxicity. We report a case of severe onycholysis as a result of treatment with docetaxel in a patient who suffered from metastatic nasopharyngeal carcinoma. The case report will be followed by a discussion on the possible mechanism and preventive strategies for taxane-induced nail toxicity.