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Article Dans Anglais | IMSEAR | ID: sea-42756

Résumé

BACKGROUND: The validity ofHachinski Ischemic Score (HIS) in differentiating between Alzheimer's disease (AD) and Vascular dementia (VaD) has been questioned and compared with the gold standard autopsy. OBJECTIVE: To confirm that the HIS can be used to differentiate related VaD from AD in a Thai population. MATERIAL AND METHOD: A prospective study of 398 patients who were attending the Memory Clinic, at Siriraj Hospital between January 2001 and October 2003. RESULTS: The 214 patients, with a mean age of 71.15 + 10.20 years, were classified as AD, VaD or mixed dementia (AD with cerebrovascular disease) in proportion of 60.2%, 30.4%, and 9.3% respectively. The authors propose HIS at 5 as a cut off point to differentiate patients with AD and those with VaD or AD with cerebrovascular disease with sensitivity of 85.3% and specificity of 72.9%. CONCLUSION: The HIS can be applied to differentiate dementia related vascular etiology from AD in a Thai population.


Sujets)
Sujet âgé , Sujet âgé de 80 ans ou plus , Maladie d'Alzheimer/diagnostic , Démence vasculaire/diagnostic , Diagnostic différentiel , Femelle , Humains , Mâle , Adulte d'âge moyen , Tests neuropsychologiques , Études prospectives , Sensibilité et spécificité , Thaïlande
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