Résumé
Successful management of parturition induction is a challenging task in canine. This study made to assess the efficacy of antiprogestagen mifepristone and prostaglandin misoprostol in induction of parturition in bitches. Total of 11 pregnant bitches with gestational age of more than 62 days confirmed by ultrasound scanning and not showing any sings of initiation of parturition were selected. Induction of parturition was initiated by mifepristone (3 mg/ kg b wt PO) twice a day or a combination of mifepristone (3 mg/kg b wt PO) and misoprostol (200 ?g for < 20 kg, 400 ?g for > 20 kg b wt, i/vg) 12 h after second dose of mifepristone. The combination of both drugs mifepristone and misoprostol was more effective for parturition induction.
Résumé
Canine pyometra is an acute or chronic polysystemic diestrual disorder mainly of mature nulliparous bitches. In this retrospective study, an attempt was made to analyse the physiological and haemato-biochemical parameters of a total of 22 affected bitches attended at Sneh Vet lab and Clinic Bhadra, Bhiwani, (Haryana). The findings revealed pyrexia and tachycardia with normal respiration rate in most of the pyometra affected bitches. Amongst the haemato-biochemical parameters, there were reduced levels of haemoglobin, packed cell volume and total erythrocyte count, along with severe leucocytosis, neutrophilia with shift to left, lymphopenia, eosinophilia and elevated BUN and serum creatinine in the bitches affected with pyometra suggesting bone marrow and renal damage. However, the mean values of mean corpuscular volume, mean corpuscular haemoglobin as well as serum ALT and AST were within the normal range, confirming normocytic normochromic anaemia without liver dysfunction.
Résumé
Background: Gestational trophoblastic diseases (GTDs) had been associated with significant morbidity and mortality till recently. Wide variation in incidences have been reported worldwide. The present study was planned with the objective of determination of incidence, assessment of risk factors, clinical presentation, management protocols and outcomes in GTD cases in Indian population at a tertiary care centre.Methods: All the diagnosed cases of GTD reporting to study centre during study period of 1.5 years were included. Detailed history taking, examination and relevant investigations (Hb%, blood grouping, thyroid functions, serum ß-hCG, USG and chest X-ray) were undertaken. Suction and evacuation were done for all patients as primary mode of management and samples were sent for histopathological examination. Comprehensive follow ups were done, including weekly ß-hCG until normal for 3 consecutive weeks followed by monthly determination until the levels were normal for 6 consecutive months.Results: Total 22 cases out of 19500 deliveries were diagnosed as GTD (incidence rate-1.13/1000 deliveries). Mean age was 23.64±3.89 years with 50% participants being primigravida. The commonest symptom after amenorrhea 22 (100%) was bleeding per-vaginum 15 (68.2%). Maximum cases were of complete hydatidiform mole histopathology 16 (72.73%), USG 19 (86.4%). Clinical characteristics were statistically comparable between patients of complete mole and partial mole. Out of 22 cases, 1 (4.5%) was diagnosed as GTN.Conclusions: Early diagnosis and treatment along with regular follow up is the key in GTD. There is need to establish a centralized disease specific registry in future.