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1.
Indian J Dermatol Venereol Leprol ; 2013 Nov-Dec; 79(6): 759-771
Article Dans Anglais | IMSEAR | ID: sea-154675

Résumé

Acitretin, a synthetic retinoid has gradually replaced etretinate in today’s dermatologic practice because of its more favorable pharmacokinetics. Acitretin over the past 20 years has proven useful in a number of diffi cult-to-treat hyperkeratotic and infl ammatory dermatoses and nonmelanoma skin cancers. It is effective both as monotherapy and in combination with other drugs for hyperkeratotic disorders. It is considered to be an established second line treatment for psoriasis and exerts its effect mainly due to its antikeratinizing, antiinfl ammatory, and antiproliferative effect. Its antineoplastic properties make it a useful agent for cancer prophylaxis. Evidence-based effi cacy, side-effect profi le, and approach to the use of acitretin would be discussed in this review. In addition to its approved uses, the various off label uses will also be highlighted in this section. Since its use is limited by its teratogenic potential and other adverse effects, including mucocutaneous effects and hepatotoxicity, this review would summarize the contraindications and precautions to be exercised before prescribing acitretin.


Sujets)
Acitrétine/administration et posologie , Acitrétine/pharmacocinétique , Animaux , Antinéoplasiques/administration et posologie , Antinéoplasiques/pharmacocinétique , Différenciation cellulaire/effets des médicaments et des substances chimiques , Différenciation cellulaire/physiologie , Dermatologie/méthodes , Dermatologie/tendances , Humains , Kératolytiques/administration et posologie , Kératolytiques/pharmacocinétique , États précancéreux/anatomopathologie , États précancéreux/prévention et contrôle , Absorption cutanée/effets des médicaments et des substances chimiques , Absorption cutanée/physiologie , Maladies de la peau/traitement médicamenteux , Maladies de la peau/anatomopathologie
3.
Indian Pediatr ; 2013 February; 50(2): 256
Article Dans Anglais | IMSEAR | ID: sea-169704
4.
Indian J Dermatol Venereol Leprol ; 2013 Jan-Feb; 79(1): 17-29
Article Dans Anglais | IMSEAR | ID: sea-147389

Résumé

Reticulate pigmentary disorders is a term that is loosely defined to include a spectrum of acquired and congenital conditions with different morphologies. The presentations vary from the reticular or net like pattern to the" freckle like" hyper and hypopigmented macules that are usually restricted to the true genetic "reticulate" pigmentary disorders. There is little clarity on this topic and related terms, in major dermatology textbooks. Hence, to harmonize the different entities we feel that the term "mottled pigmentation" could be used to include reticulate pigmentary disorders (acquired and congenital), dyschromasias and the disorders with a reticular pattern. The genetic reticulate pigmentary disorders can also be classified according to the gene loci which in the majority of cases are localized to keratin 5/14. A more useful clinical method of classification is based on the regional distribution, which includes facial, truncal, acral or flexural types. In this review we will largely focus on the inherited reticulate pigmentary disorders.


Sujets)
Humains , Hyperpigmentation/induit chimiquement , Hyperpigmentation/classification , Hyperpigmentation/génétique , Troubles de la pigmentation/induit chimiquement , Troubles de la pigmentation/classification , Troubles de la pigmentation/génétique , Peau
5.
Indian J Dermatol Venereol Leprol ; 2012 Jul-Aug; 78(4): 417-428
Article Dans Anglais | IMSEAR | ID: sea-141126

Résumé

Melasma is one of the most common and distressing pigmentary disorders presenting to dermatology clinics. The precise cause of melasma remains unknown; however, there are many possible contributing factors. It is notably difficult to treat and has a tendency to relapse. The existing and most tried topical therapy is hydroquinone and the triple combination with tretinoin and corticosteroids, which is considered the gold standard for melasma. Besides that, azelaic acid, kojic acid, arbutin, ascorbic acid, glycolic acid and salicylic peels have also been tried with limited success. However, multiple novel topical agents are being investigated for their potential as hypopigmenting agents with unique mode of action. But, further trials are required to study their efficacy and safety before they can be further recommended. The article highlights these newer formulations and also briefly mentions about the newer chemical peels and the much hyped lasers in treating this difficult and frustrating condition.

6.
Indian J Dermatol Venereol Leprol ; 2012 Mar-Apr; 78(2): 187-189
Article Dans Anglais | IMSEAR | ID: sea-141045
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