Résumé
Correlation between the intrahepatic inflammatory pathogenesis and the TCM theory of liver collateral injury by toxins in patients of type 2 diabetes mellitus (T2DM) with insulin resistance (IR) was investigated, to elucidate that removing toxins, dredging collateral and modulating Gan could be one of the effective approaches for inhibiting intrahepatic inflammation mechanism of T2DM with IR.
Sujets)
Humains , Chimiokine CCL2 , Métabolisme , Diabète de type 2 , Métabolisme , Diagnostic différentiel , Inflammation , Métabolisme , Insulinorésistance , Foie , Métabolisme , Anatomopathologie , Médecine traditionnelle chinoise , Facteur de transcription NF-kappa B , MétabolismeRésumé
Aim of this article was to investigate relationship between inflammatory pathogenesis of diabetic nephropathy and the TCM pathogenetic theory of Shen-Collateral impaired by Toxin, and to illustrate the method for removing toxin, activating collateral and protecting Shen can be an effective treatment for inhibiting the inflammatory pathogenesis of diabetic nephropathy.
Sujets)
Femelle , Humains , Mâle , Chimiokine CCL2 , Génétique , Néphropathies diabétiques , Traitement médicamenteux , Métabolisme , Diagnostic différentiel , Médicaments issus de plantes chinoises , Utilisations thérapeutiques , Inflammation , Métabolisme , Médecine traditionnelle chinoise , Facteur de transcription NF-kappa B , Génétique , PhytothérapieRésumé
<p><b>OBJECTIVE</b>To observe the therapeutic effect of xiaoke shen' an capsule on diabetic nephropathy.</p><p><b>METHODS</b>Ninety patients with diabetic nephropathy were randomly divided into two groups, the patients in the control group (CG) were treated with conventional western medicine, and those in the treated group (TG) were treated with combined therapy of xiaoke shen'an capsule and conventional western medicine. The treatment course of both groups was 8 weeks, and the therapeutic effect related indexes were measured before and after treatment.</p><p><b>RESULTS</b>The curative rate was 85.0% and 73.3% in CG and TG respectively, it was better in TG than that in CG (P < 0.05). Indexes such as fasting blood glucose, glycosylated hemoglobin, blood pressure, quantity of 24h urinary protein, urinary albumin excretion rate, renal function, blood lipids and hemoreheologic parameters were significantly different before and after treatment in TG (P < 0.05 or P < 0.01). As compared with CG, some of these indexes after treatment were superior to those in CG (P < 0.01 or P < 0.05).</p><p><b>CONCLUSION</b>Combined therapy of xiaoke shen'an capsule and conventional western medicine has definite therapeutic effect on diabetic nephropathy.</p>