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Objective To evaluate the efficacy and adverse events of irinotecan (CPT-11) combined with 5-FU in treatment of patients with advanced rectal cancer. Methods 86 patients were randomly divided into FOLFIRI treatment group and IFL treatment group. The efficacy and adverse events were observed. Results There was no statistically significant difference between FOLFIRI treatment group and IFL treatment group in CR、PR、SD and RR(all P ＞ 0. 05). There was also no statistically significant difference between FOLFIRI treatment group and IFL treatment group in adverse events(all P ＞ 0.05). Conclusion Irinotecan in combination with 5-FU was effective and had some tolerable adverse events in treating patients with advanced rectal cancer in both FOLFIRI treatment group and IFL treatment group.
Résumé
OBJECTIVE:To observe clinical efficacy of reduced glutathione in the treatment of chemotherapeutics-induced liver lesion in cancer patients.METHODS:85 patients with drug-induced liver lesion after chemotherapy were randomly divided into 2 groups.Treatment group were treated with reduced glutathione and diammonium glycyrrhizinate injection (n=43) and control group were treated with diammonium glycyrrhizinate (n=42).Clinical efficacies of 2 groups were compared.RESULTS:After 2 weeks,average value of several index in treatment group were lower than in control group,there were significant difference between 2 groups (P