Résumé
Objective:To observe the effects of Er ∶YAG(erbium:yttrium-aluminum-garnet) laser combined with diode laser in the treatment of chronic periodontitis.Methods:30 patients with chronic periodontitis patients were treated by mechanical scaling and root planning(SRP),pure Er ∶ YAG laser(ERT),diode + Er ∶ YAG + diode laser therapy(TPT) respectively.In the treatment VAS pain score was recorded.Probing deepth (PD),clinical attachment level (CAL) and bleeding on probing (BOP) were examined,IL-1 β,TNF-α and b-FGF in GCF,Porphyromonas gingivalis(Pg) in subgingiva plaqure were measured before and after treatment.Data were analyzed by SPSS 21.0 software.Results:6 weeks,12 weeks after treatment PD,BOP and CAL in TPT group were lower than those in ERT and SRP groups(P ＜0.05),TGF-β and b-FGF in TPT group were higher,IL-1β and TNF-α were lower than those in ERT and SRP groups (P ＜ 0.05).The content of Pg relative to total bacteria in TPT group were lower than that in ERT and SRP groups (P ＜ 0.05),VAS value in twinlight laser group was significantly lower than hand instruments group(P ＜ 0.05).Conclusion:The twinlight laser is effective in the treatment of periodontitis.
Résumé
Objective:To investigate the protective effects of quercetin on the periodontal tissue in Wistar rats with periodontitis. Methods:30 Wistar rats were randomly divided into 3 groups(n =1 0):Control group (group N),ligation group(group L)and liga-tion +quercetin group(group LQ).Bilateral first molars of the rats in group L and LQ were cervically ligated by an orthodontic wire with the diameter of 0.2 mm.The rats in group LQ were then treated with quercetin by gavage at 50 mg/(kg·d)after ligation.After 8 weeks,the rats were killed.Continuous slices of the periodontal tissue were made for HE staining and immunohistochemistry stai-ning.The morphological changes and the expression of TNF-αand COX-2 in the periodontal tissue were observed under light micro-scope.Results:The inflammatory cells and periodontal pocket were observed in group LQ were less than those in group L.The levels of TNF-α,COX-2 in group LQ were lower than that those in the group L(P <0.05).Conclusion:Quercetin has a protective effect on the periodontal tissues of Wistar rats with periodontitis.