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Impact of Bacille Calmette-Guérin revaccination on serum IgE levels in a randomized controlled trial
Rev. Soc. Bras. Med. Trop
; 51(1): 94-98, Jan.-Feb. 2018. tab, graf
Article
de Anglais
| LILACS
| ID: biblio-1041447
RÉSUMÉ
Abstract INTRODUCTION: Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection. METHODS: Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial. RESULTS: Serum total or Derp-specific IgE levels did not change regardless of the increase in IFN-γ levels. CONCLUSIONS: BCG responsiveness does not affect protection against atopy.