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Objective:To discuss the mechanism of Yueju Pill in the treatment of functional dyspepsia (FD) based on network pharmacology and molecular docking.Methods:The chemical components and action targets of Yueju Pill were screened out by TCMSP platform and HERB, BATMAN-TCM database combined with literature were used to supplement effective components of Vietnam bow. The targets of FD were screened out by GeneCards database and OMIM database, and the intersection of the two targets was used to analyze the protein interactions using the STRING platform to construct the PPI network. Metascape platform was used for GO and KEGG pathway enrichment analysis, and Cytoscape 3.7.2 software was used to construct a network of "Yueju Pill components-functional dyspepsia targets-pathways". Online mapping tools were used to obtain the Venn plot of the intersection targets of Yueju Pill, FD and its related pathogenesis. Finally, AutoDock software was used for molecular docking.Results:The main active components of Yueju Pill in the treatment of FD are quercetin, wogonin, luteolin, kaempferol, etc. The main targets are AKT1, MAPK1, JUN, RELA, IL6, BCL2, BAX, MAPK8, EGFR, ESR1, etc. Molecular docking shows that the targets and the active components of the Yueju Pill have better binding abilit. The GO enrichment analysis result shows that there are 2 273 biological processes, 152 molecular functions and 91 cell components. KEGG enrichment analysis shows that there are 344 pathways associated with FD. According to literature review, the pathways related to FD include PI3K-Akt signaling pathway, AGE-RAGE signaling pathway, IL-17 signaling pathway, etc.Conclusion:Yueju Pill might act on AKT1, MAPK1, JUN, RELA, IL6, BCL2, BAX, MAPK8, EGFR, ESR1 and other targets to regulate PI3K-Akt signaling pathway, AGE-RAGE signaling pathways and IL-17 signaling pathway and it could treat FD.
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Objective To evaluate the effect ofBazheng powder combined with levofloxacin on renal tissue injure of patients after renal extracorporeal shockwave lithotripsy.Methods A total of 100 patients with renal calculus were randomly divided into a Bazheng powder group (50 patients) and a control group (50 patients). ESWL was used in the 2 groups. After ESWL operation, patients in the control group were administered with large amount of drinking water and appropriate exercises to promote stone removal. And on this basis, ethanesulfonic acid levofloxacin was administered for successive 3 days. TheBazheng powder group was additionally addedBazheng powder on the basis of the control group for 15 days. 15 days later, C Cys and NGAL and therapeutic effect in both groups were evaluated.Results The total effective rate of theBazheng powder group was significantly better than the control group (96%vs. 60%,χ2=16.842,P<0.01). The serum Cys C (0.97 ± 0.10 mg/Lvs. 1.13 ± 0.25 mg/L,t=4.202) and NGAL(4.04 ± 1.32 g/Lvs. 6.91 ± 2.96 g/L,t=6.262) in the Bazheng powder group decreased, the serum Cys C (0.95 ± 0.12 mg/Lvs. 1.09 ± 0.20 mg/L,t=4.244) and NGAL(4.66 ±1.57 g/Lvs. 7.19 ± 1.81 g/L,t=7.762) levels in the control group were also decreased after the treatment (P<0.01), andBazheng powde group of postoperative urinary NGAL level was significantly lower than the control group (t=2.137,P=0.035).ConclusionBazheng powder combined with ESWL can accelerate renal calculi removal and repair renal injury after ESWL operation. We also speculate that the best interval is 2 weeks for two lithoclasty operation.
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Statins are a class of cholesterol-lowering drugs for effectively reducing the risk of cardiovascular events,including myocardial infarction and stroke.Clinical trials and meta-analyses have shown that the treatment with statins may increase the risk of new-onset diabetes mellitus.This article reviews the evidence of statins inducing diabetes mellitus,the possible mechanisms,and clinical significance.