1.
Braz. j. microbiol
;
34(1): 1-4, Jan.-Apr. 2003. tab
Article
Dans Anglais
| LILACS
| ID: lil-344555
Résumé
Mutants of Aspergillus niger N402, induced by UV mutagenesis, were selected and tested for resistance or sensitivity to 5-fluorocytosine. Some mutants showed increased citric acid production, which did not correlate with the intracellular amount of protein or ammonium ion. The resistance to 5-fluorocytosine proved to be a rational approach for isolation of new mutants with improved production of citric acid. The best mutant (FR13) accumulated double the amount of citric acid produced by the parental strain.