Corpus gastritis and erosive esophagitis: a report from the Middle East.

OBJECTIVE: To assess whether corpus gastritis due to Helicobacter pylori protects against erosive esophagitis in an area with high prevalence of H. pylori infection. METHODS: Biopsies obtained from gastric corpus and antrum in 151 patients with symptoms of gastroesophageal reflux disease were studied for presence of H. pylori and endoscopic evidence of gastritis. Presence and grade of esophagitis at endoscopy was recorded. RESULTS: Fifty-four (36%) patients had endoscopic esophagitis. Patients with severe esophagitis (>or= grade II) less often had active gastritis (15/45 vs. 55/98; p=0.02) and had a lower density of H. pylori (p=0.0003) than those without esophagitis. CONCLUSION: Active corpus gastritis due to H. pylori infection may protect against erosive esophagitis in patients with gastroesophageal reflux disease in the Middle East.

Impact of magnetic resonance cholangiography on endoscopic therapy before and after laparoscopic cholecystectomy.

OBJECTIVE: To assess the impact of magnetic resonance cholangiography (MRC) on endoscopic therapy before and after laparoscopic cholecystectomy (LC). METHODS: Ninety-six patients were referred for endoscopic retrograde cholangiography (ERC) before or after LC because of abnormal liver function tests, raised serum amylase, or abnormal ultrasound scan (USS) of the biliary system. All patients underwent MRC before ERC. RESULTS: Common bile duct (CBD) stones were detected in 48 patients on ERC, 40 on MRC, and 23 on USS. The CBD was dilated on ERC (> 8 mm) in 59 patients, on MRC (> 7 mm) in 51, and on USS (> 7 mm) in 42. Abnormal CBD (dilated +/- stone) was detected in 69 patients on ERC, 57 on MRC, and 44 on USS. Intrahepatic ducts were dilated on ERC in 26 patients, on MRC in 24, and on USS in 18. The study was abnormal on ERC in 81 patients, on MRC in 63, and on USS in 51. Endoscopic therapy was attempted in 80 patients. Presence of CBD stone (p = 0.03), dilated CBD (p = 0.01), abnormal CBD (p = 0.0007), and abnormal study (p = 0.0004) on MRC were significantly related to endoscopic therapy. In 6 cases LC was deferred because MRC revealed CBD calculi which could not be cleared endoscopically. ERC could have been avoided in 14/ 19 patients who did not benefit from it. CONCLUSION: MRC findings are significantly related to endoscopic therapy in patients referred for ERC before and after LC, and they influence therapeutic decisions in some of them.