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Biol. Res ; 51: 34, 2018. tab, graf
Article de Anglais | LILACS | ID: biblio-983938

RÉSUMÉ

BACKGROUND AND AIMS: Atherosclerotic cardiovascular disease is highly prevalent and its underlying pathogenesis involves dyslipidemia including pro-atherogenic high density lipoprotein (HDL) remodeling. Vitamins C and E have been proposed as atheroprotective agents for cardiovascular disease management. However, their effects and benefits on high density lipoprotein function and remodeling are unknown. In this study, we evaluated the role of vitamin C and E on non HDL lipoproteins as well as HDL function and remodeling, along with their effects on inflammation/ oxidation biomarkers and atherosclerosis in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice. METHODS AND RESULTS: Mice were pre-treated for 5 weeks before and during atherogenic diet feeding with vitamin C and E added to water and diet, respectively. Compared to a control group, combined vitamin C and E administration reduced serum total cholesterol and triglyceride levels by decreasing apo B-48-containing lipoproteins, remodeled HDL particles by reducing phospholipid as well as increasing PON1 and apo D content, and diminished PLTP activity and levels. Vitamin supplementation improved HDL antioxidant function and lowered serum TNF-α levels. Vitamin C and E combination attenuated atherogenesis and increased lifespan in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice. CONCLUSIONS: Vitamin C and E administration showed significant lipid metabolism regulating effects, including HDL remodeling and decreased levels of apoB-containing lipoproteins, in mice. In addition, this vitamin supplementation generated a cardioprotective effect in a murine model of severe and lethal atherosclerotic ischemic heart disease.


Sujet(s)
Animaux , Mâle , Femelle , Acide ascorbique/pharmacologie , Vitamine E/pharmacologie , Ischémie myocardique/prévention et contrôle , Apolipoprotéine B-48/effets des médicaments et des substances chimiques , Hyperlipidémies/prévention et contrôle , Lipoprotéines HDL/effets des médicaments et des substances chimiques , Antioxydants/pharmacologie , Valeurs de référence , Maladie des artères coronaires/prévention et contrôle , Maladie des artères coronaires/sang , Test ELISA , Cardiotoniques/pharmacologie , Immunotransfert , Reproductibilité des résultats , Cytokines/sang , Résultat thérapeutique , Ischémie myocardique/sang , Compléments alimentaires , Protéines de transfert des phospholipides/sang , Régime athérogène , Récepteurs éboueurs de classe B/effets des médicaments et des substances chimiques , Récepteurs éboueurs de classe B/sang , Métabolisme lipidique/effets des médicaments et des substances chimiques , Apolipoprotéine B-48/sang , Hyperlipidémies/sang , Lipoprotéines HDL/sang , Souris de lignée C57BL
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