Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
Chinese Journal of Medical Genetics ; (6): 155-158, 2012.
Article Dans Chinois | WPRIM | ID: wpr-295517

Résumé

<p><b>OBJECTIVE</b>To assess the association between brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism and clinical characteristics of first episode schizophrenia in a Chinese Han population.</p><p><b>METHODS</b>Genotyping of BDNF Val66Met polymorphism was carried out for 135 schizophrenic patients and 483 healthy controls with TaqMan probe technology. The patients' psychotic symptoms were assessed using the positive and negative syndrome scale (PANSS).</p><p><b>RESULTS</b>A significant difference was found in genotype distribution and allelic frequency of the Val66Met polymorphism between the two groups (P< 0.01). In patients, Met homozygotes had a significantly higher score in anxiety/depression factor, cognitive factor and total score of PANSS than Val carriers.</p><p><b>CONCLUSION</b>BDNF gene Val66Met polymorphism is associated with the pathogenesis of schizophrenia. The Met/Met genotype of BDNF Val66Met variant may be a risk factor for symptoms in first episode schizophrenia patients.</p>


Sujets)
Adolescent , Adulte , Femelle , Humains , Mâle , Adulte d'âge moyen , Jeune adulte , Facteur neurotrophique dérivé du cerveau , Génétique , Chine , Fréquence d'allèle , Prédisposition génétique à une maladie , Génotype , Polymorphisme de nucléotide simple , Schizophrénie , Génétique
SÉLECTION CITATIONS
Détails de la recherche