Effect of coenzyme Qio on radiation-induced fatigue in rats

Background: Fatigue is a common side effect in cancer patients undergoing radiation therapy [RT]. Radiation-induced fatigue affects the quality of life, but there is no definitive treatment option, in this study, the weight-loaded forced swim test was performed to assess the effect of coenzyme QIO [CoQIO] on radiation-induced fatigue

Materials and Methods: A total of 60 rats were divided randomly and equally into four groups: No swim, No RT, RT + placebo, or RT + CoQIO. The No swim, No RT, and RT + placebo groups received 1 ml of soybean oil daily for 14 days. The RT + CoQIO group received 100 mg/kg of CoQIO in soybean oil at the same times. Both RT groups were irradiated with 10 Gy on the 14th day of treatment. The swim test with sinkers weighing 10% of body weight was performed 24 h later in all animals except the No swim group

Results: The level of blood urea nitrogen [BUN] was significantly lower in the No swim than the other groups. The BUN level of the No RT group was significantly decreased compared with the RT + placebo group, but it did not differ from the RT + CoQIO group. Swimming times to complete exhaustion were significantly longer in the No RT and RT + CoQIO groups compared to the RT + placebo group [99.4, 105.9, and 75.7 s, respectively] [P<0.001]

Conclusion: Supplementation with CoQIO can prevent the decrease in endurance capacity caused by radiation

Neuroimaging in ophthalmology

In the past three decades, there have been countless advances in imaging modalities that have revolutionized evaluation, management, and treatment of neuro-ophthalmic disorders. Non-invasive approaches for early detection and monitoring of treatments have decreased morbidity and mortality. Understanding of basic methods of imaging techniques and choice of imaging modalities in cases encountered in neuro-ophthalmology clinic is critical for proper evaluation of patients. Two main imaging modalities that are often used are computed tomography [CT and magnetic resonance imaging [MRI]. However, variations of these modalities and appropriate location of imaging must be considered in each clinical scenario. In this article, we review and summarize the best neuroimaging studies for specific neuro-ophthalmic indications and the diagnostic radiographic findings for important clinical entities