Acute haemodynamic effects of intravenous ICI 153,110 in congestive heart failure

Despite recent advances in the pharmacological and mechanical means of supporting ventricular function, congestive heart failure continues to be major cause of morbidity and mortality. Impaired myocardial contractility remains to be a primary feature. Phosphodiesterase inhibition can lead to an increase in cyclic AMP and augment myocardial contractility. The results in this study suggest that the positive inotropic drug may be beneficial for the treatment of Congestive heart failure. Furthermore ICI 153, 110 proves to be effective positive inotropic drug with vasodilating effects and does improve left ventricular performance during acute administration in patients with congestive heart failure