Résumé
In this study, we described two, unrelated adult, female and male patients. They developed sever fatigue, weakness, anxiety postural hypotension and hypoglycemia. Progressive alopecia areata with impairment of antrograde memory were also present. Marked hypocortisolemia, Anti bodies to some endocrinal cells. Associated with radiological abnormalities in the hippocampus were detected. The similarity between these two cases and the uncommon nature of the component abnormalities suggest the involvement of a molecular target for autoimmunity shared among hippocampus, hair follicle and the hypothalamus and/or corticotrophin, it is the cause of its name "Triple H. Syndrome". A German female 41 years old presented to the endocrine department of AI- Aahraa university Hospital in September 2002 with total loss of body hair. In year 2000 the patient noticed progressive constipation, loss of appitite and sleeping tendency. This was associated with loss of memory specially for recent events. Laboratory investigation in the form of free T[3], free T[4], TSH and thyroid AB were done [Table 1], and the patient was diagnosed as having hypothyroidism. She received medical treatment in the form of EI-Troxin 75 Mic. gm/d. and the condition gradually improved. After 7 months of treatment the patient became pregnant, after delivery she started to lose scalp hair gradually, followed tow months later by loss of eye brows, axially and pubic hair. Subsequently she complained of fatigue, memory loss especially for recent events along with symptoms of hypertension and repeated hypoglycemic attacks