Synthesis and pharmacological studies of 1, 3-disubstituted malonic acids

A new series of 1, 3-disubstituted malonic acid compounds [I-IX] were prepared via the reaction of malonyl di-chloride with the selected amino acids [P-alanine, glycine and aspartic acid] and their ethyl and propyl esters respectively. Structure of all the synthesized compounds have been elucidated by I.R. Synthesized compounds were found to be pharmacologically active and showed sedative-hypnotic activity and positive behavioral changes