Prevalence of mild visual impairment in type 2 diabetes patients over 50 years old in Funing County: Jiangsu Diabetic Eye Disease Study / 中华实验眼科杂志

Objective:To investigate the prevalence and influencing factors of mild visual impairment in type 2 diabetic patients aged ≥50 years living in Funing County, Jiangsu Province.Methods:A population-based cross-sectional study was adopted.Cluster sampling was conducted among diabetic patients aged ≥50 years registered in the Chronic Disease Information Center of Funing County Center for Disease Prevention and Control from March 7th to April 20th, 2019.General information of selected patients was collected.Visual and ocular examinations on site were performed by ophthalmologists and technicians.The International Council of Ophthalmology standard for mild visual impairment, 0.3≤best corrected visual acuity<0.8 was adopted.The influencing factors of mild visual impairment were analyzed by logistic regression.This study protocol was approved by the Ethics Committee of Affiliated Hospital of Nantong University (No.2014-071).Results:Among the included 2 067 patients, 1 909 cases completed the investigation, with a response rate of 92.4%.There were 1 146 patients with mild visual impairment in at least one eye, and the prevalence of mild visual impairment was 60.00%.Among the eyes examined, 1 832 eyes were with mild visual impairment, accounting for 47.98%.Cataract (896/1 632), refractive error (515/1 632) and diabetic retinopathy (166/1 632) were the main causes of mild visual impairment in diabetic patients, accounting for 54.90%, 31.61% and 10.19%, respectively.Aging, female gender, low educational attainment, oral hypoglycemic drugs or subcutaneous insulin injection were risk factors for mild visual impairment in both eyes.Higher educational attainment, more sunshine exposure and exercise were protective factors for mild visual impairment in both eyes.Conclusions:The prevalence of mild visual impairment is relatively high in type 2 diabetic patients.Cataract surgery, correction of refractive error may help to improve mild visual impairment.Strengthening blood glucose control, more physical exercise and outdoor activities may slow the progression of mild visual impairment and prevent it from moderate and severe visual impairment.

The practice of CAD custom femoral prosthesis and the computer simulated biomechanical experiment / 生物医学工程学杂志

The present study was carried out to verify the accuracy and feasibility of the CAD program and to demonstrate whether the custom prosthesis is superior to the commercial ones. We modified the previously developed CAD (computer aided design) program, and buildt up a three-dimensional (3D) model of the custom femoral prosthesis by using the modified program and Canny algorithm; therefore, a basic foundation for the CAM (computer aided manufacture) was laid. Through the computer simulated biomechanical experiment on the prostheses, we came to the conclusion that the custom designed prosthesis has a better biomechanical characteristic. The future for this kind of prosthesis in THA(total hip arthroplasty) is very promising and it can be successfully applied in clinical practice through the CAM.

Imbalance of T cell subpopulations in immunologic pathogenesis of throm boangiitis obliterans / 中国免疫学杂志

The T cell subpopulations of peripheral blood from 60 TAO patients and 40 normal subjects were detected with 3 kinds of monoclonal antibodies using indirect immunofluoresence technique. Meanwhile, the antiarterial antibodies (AAA) and circulating immune complex (CIC) from the sera of above patients and normal subjects were also determined. The results of the experiment suggests: (1) The functional disorders of immunoreguiating T cell (T4~+, T8~+),especially the severe decrease of T8~+ cell percentage play an important role in the pathogenesis of TAO;(2) The imbalance of T cell subpopulations have close relation to the production of antiarterial antibodies.