Résumé
Metabolic syndrome is highly prevalent among population nowadays. Non-alcoholic steatohepatitis is so common in the cases of metabolic syndrome to the extent that it is considered one of its criteria. Elevated Homocysteine and fibrinogen levels can increase blood coagulability, and they are considered as minor risk factors for coronary artery disease. Recent studies have suggested that they may also have a role in the pathogenesis of non-alcoholic steatohepatitis as well. is to detect the state of the plasma homocysteine and fibrinogen in cases of metabolic syndrome with non-alcoholic steatohepatitis and their correlation with the grade of non-alcoholic steatohepatitis. This study was done on 70 patients with metabolic syndrome their age 36-64 years, in addition to 50 healthy control subjects. They have undergone thorough history taking, clinical examination, routine investigations, liver biopsy [only in patients] and detection of plasma homocysteine and fibrinogen. 44 cases [62.9%] were found to have non-alcoholic steatohepatitis who hade also a significantly higher level of plasma homocysteine, fibrinogen and C-reactive protein [P < 0.0001] in comparison to those had no non-alcoholic steatohepatitis. Moreover, the grade of non-alcoholic steatohepatitis had a significant positive correlation with homocysteine and C-reactive protein [P < 0.0001]. The level of plasma homocysteine, fibrinogen and C-reactive protein is higher in cases with non-alcoholic steatohepatitis than in those without it suggesting that they can be predictors for the disease, but this needs further confirmation by large prospective studies