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1.
Article Dans Anglais | IMSEAR | ID: sea-148173

Résumé

Background & objectives: Malachite green (MG), an environmentally hazardous material, is used as a non permitted food colouring agent, especially in India. Selenium (Se) is an essential nutritional trace element required for animals and humans to guard against oxidative stress induced by xenobiotic compounds of diverse nature. In the present study, the role of the selenium compound diphenylmethyl selenocyanate (DMSE) was assessed on the oxidative stress (OS) induced by a food colouring agent, malachite green (MG) in vivo in mice. Methods: Swiss albino mice (Mus musculus) were intraperitoneally injected with MG at a standardized dose of 100 μg/ mouse for 30 days. DMSE was given orally at an optimum dose of 3 mg/kg b.w. in pre (15 days) and concomitant treatment schedule throughout the experimental period. The parameters viz. ALT, AST, LPO, GSH, GST, SOD, CAT, GPx, TrxR, CA, MN, MI and DNA damage have been evaluated. Results: The DMSE showed its potential to protect against MG induced hepatotoxicity by controlling the serum alanine aminotransferase and aspartate amino transferase (ALT and AST) levels and also ameliorated oxidative stress by modulating hepatic lipid peroxidation and different detoxifying and antioxidative enzymes such as glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), and also the selenoenzymes such as glutathione peroxidase (GPx) and thioredoxin reductase (TrxR) and reduced glutathione level which in turn reduced DNA damage. Interpretation & conclusions: The organo-selenium compound DMSE showed significant protection against MG induced heptotoxicity and DNA damage in murine model. Better protection was observed in pretreatment group than in the concomitant group. Further studies need to be done to understand the mechanism of action.

2.
Indian J Ophthalmol ; 2011 May; 59(3): 231-233
Article Dans Anglais | IMSEAR | ID: sea-136177

Résumé

An 18-year-old woman was referred with late sequelae of chloroquine-induced Steven–Johnson syndrome. At the time of presentation, the symblepharon was involving the upper lids to almost the whole of the cornea, and part of the lower bulbar conjunctiva with the lower lid bilaterally. Other ocular examinations were not possible due to the symblepharon. B-scan ultrasonography revealed acoustically clear vitreous, normal chorioretinal thickness, and normal optic nerve head, with an attached retina. Conjunctivo-corneal adhesion released by superficial lamellar dissection of the cornea. Ocular surface reconstruction was carried out with a buccal mucous membrane. A bandage contact lens was placed over the cornea followed by the symblepharon ring to prevent further adhesion. The mucosal graft was well taken up along with corneal re-epithelization. Best corrected visual acuity of 20/120 in both sides after 1 month and 20/80 after 3 months was achieved and maintained till the 2.5-year follow-up.


Sujets)
Adolescent , Maladies de la conjonctive/étiologie , Maladies de la conjonctive/chirurgie , Femelle , Humains , Muqueuse/transplantation , Syndrome de Stevens-Johnson/complications , Adhérences tissulaires/étiologie , Adhérences tissulaires/chirurgie
3.
Indian J Dermatol Venereol Leprol ; 2009 May-June; 75(3): 321-322
Article Dans Anglais | IMSEAR | ID: sea-140369
4.
Indian J Dermatol Venereol Leprol ; 2008 Sep-Oct; 74(5): 516-8
Article Dans Anglais | IMSEAR | ID: sea-53026
6.
Indian J Ophthalmol ; 2008 Mar-Apr; 56(2): 153-5
Article Dans Anglais | IMSEAR | ID: sea-69911

Résumé

We present the clinical profile of biopsy and immunohistochemistry-proven ocular adnexal lymphomas in the Northeast Indian population. Nineteen patients between October 2004 and June 2006 with ocular adnexal lymphoma were analyzed retrospectively. Histopathological classification was done according to international working formulation. Twelve patients were male and seven were female. All were diagnosed as non-Hodgkin's lymphoma and the majority were B cell type (89%). Most of the cases (42%)were treated with radiotherapy followed by chemotherapy.

7.
Indian J Dermatol Venereol Leprol ; 2008 Jan-Feb; 74(1): 80
Article Dans Anglais | IMSEAR | ID: sea-53092

Résumé

Genital involvement in porokeratosis (PK) is a rare occurrence even in disseminated forms. We encountered three patients who had porokeratosis affecting only the genital area. Two of them were male with involvement of the penis and scrotum and only the scrotum respectively. The lady with vulvar involvement is a hitherto unreported instance of porokeratosis confined to female genitalia. None of the cases were very easy to diagnose clinically but biopsies proved confirmatory. The male patients were advised light electrocautery under local anesthesia while the female patient underwent surgical excision.No malignant change has been reported in them till date.


Sujets)
Adulte , Femelle , Humains , Mâle , Pénis , Porokératose/anatomopathologie , Scrotum , Peau/anatomopathologie , Vulve
8.
Indian J Exp Biol ; 2007 May; 45(5): 413-8
Article Dans Anglais | IMSEAR | ID: sea-59312

Résumé

In a bid to ascertain the molecular architecture of the silver positive regions (NORs) in chromosomes of three species of fish, namely, Hemibagrus menoda (Hamilton), Sperata seenghala (Sykes) (Fam: Bagridae) and Mastacembelus armatus (Lacep6de) (Fam: Mastacembelidae), an additional staining methodology using a fluorochrome dye (Chromomycin A3) was deployed along with the AgNO3 technique. The nucleolar organizing regions (NORs) were located terminally at the shorter arms (Tp) of one pair of submetacentric chromosomes (No.3) in H. menoda (2n=58), at the longer arms (Tq) of one pair of submetacentric chromosomes (No.5) in S. seenghala (2n=50) and at the shorter arm (Tp) of one pair of homologous submetacentric chromosomes (No.6) in M. armatus (2n=48). Staining with Chromomycin A3 produced bright fluorescing zones in GC-rich heterochromatin of Ag-positive NORs. The results indicate a more general trend of existence of an overlapping region between NOR and GC-rich fluorescing zones, the active sites of rRNA genes (rDNA) in this primitive group of vertebrates although exceptions to this situation has been reported in a couple of extant fish species earlier. More data utilizing such combined methodologies are warranted to understand the structural organization of fish chromosomes more precisely.


Sujets)
Animaux , Poissons-chats/génétique , Chromomycine A3/pharmacologie , Chromosomes/composition chimique , Colorants fluorescents/pharmacologie , Séquence riche en GC/effets des médicaments et des substances chimiques , Hétérochromatine/composition chimique , Caryotypage , Organisateur nucléolaire/composition chimique , Coloration à l'argent , Smegmamorpha/génétique
10.
Indian J Dermatol Venereol Leprol ; 2005 Nov-Dec; 71(6): 414-6
Article Dans Anglais | IMSEAR | ID: sea-52890

Résumé

Porokeratosis is a specific disorder of keratinization that has five clinical types and shows a characteristic 'cornoid lamella' on histopathology. Malignant degeneration has been described in all forms of porokeratosis. To the best of our knowledge, this is the first Indian report of multicentric squamous cell carcinoma complicating porokeratosis.


Sujets)
Abdomen , Adulte , Carcinome épidermoïde/épidémiologie , Comorbidité , Dermatoses de la main/épidémiologie , Humains , Mâle , Tumeurs primitives multiples/épidémiologie , Porokératose/épidémiologie , Tumeurs cutanées/épidémiologie , Cuisse
11.
Indian J Dermatol Venereol Leprol ; 2005 Mar-Apr; 71(2): 119-21
Article Dans Anglais | IMSEAR | ID: sea-53125

Résumé

Alagille syndrome, a rare genetic disorder with autosomal dominant transmission, manifests 5 major features: paucity of interlobular bile ducts, characteristic facies, posterior embryotoxon, vertebral defects and peripheral pulmonic stenosis. We report a 6-year-old male child who presented with a history of progressive jaundice since infancy, generalized pruritus and widespread cutaneous xanthomata. He was also found to have obstructive jaundice, pulmonary stenosis with ventricular septal defect and paucity of bile ducts in liver biopsy. Histopathology confirmed skin lesions as xanthomata. The child was diagnosed as a case of Alagille syndrome. This particular syndrome with prominent cutaneous manifestations has been rarely reported in the Indian literature.


Sujets)
Syndrome d'Alagille/sang , Enfant , Humains , Mâle , Maladies génétiques de la peau/sang
12.
Indian J Dermatol Venereol Leprol ; 2005 Mar-Apr; 71(2): 109-11
Article Dans Anglais | IMSEAR | ID: sea-52859

Résumé

Epidermolysis bullosa pruriginosa, a genetic mechanobullous disease, is characterized by pruritus, lichenified or nodular prurigo-like lesions, occasional trauma-induced blistering, excoriations, milia, nail dystrophy and albopapuloid lesions, appearing at birth or later. Scarring and prurigo are most prominent on the shins. Treatment is unsatisfactory. We report three such cases: two of them first cousins, are described with history of blisters since childhood, followed by intensely pruritic lesions predominantly on the shins, and dystrophy of toenails, but no albopapuloid lesions or milia. Intact blisters were present in one case, and excoriations were seen in the other two. All of them showed encouraging response to cryotherapy.


Sujets)
Adolescent , Adulte , Cryothérapie , Épidermolyse bulleuse/diagnostic , Femelle , Humains , Mâle
13.
Indian J Dermatol Venereol Leprol ; 2005 Jan-Feb; 71(1): 41-3
Article Dans Anglais | IMSEAR | ID: sea-53025

Résumé

Pigmented xerodermoid, a rare genodermatosis, presents with clinical features and pathology similar to xeroderma pigmentosum, but at a later age. DNA repair replication is normal, but there is total depression of DNA synthesis after exposure to UV radiation. Two siblings in their teens and a man in his thirties with features of pigmented xerodermoid, e.g. photophobia, freckle-like lesions, keratoses, dryness of skin, and hypo- and hyper-pigmentation, are described. Although classically the onset of pigmented xerodermoid is said to be delayed till third to fourth decade of life, it seems the disease may appear earlier in the tropics. Early diagnosis and management could be life-saving.


Sujets)
Administration par voie topique , Adolescent , Adulte , Ponction-biopsie à l'aiguille , Femelle , Études de suivi , Glycolates/usage thérapeutique , Humains , Immunohistochimie , Inde , Mâle , Indice de gravité de la maladie , Maladies de la peau/diagnostic , Produits antisolaires/usage thérapeutique , Rayons ultraviolets/effets indésirables , Xeroderma pigmentosum/diagnostic
14.
Indian J Dermatol Venereol Leprol ; 2004 Sep-Oct; 70(5): 304-6
Article Dans Anglais | IMSEAR | ID: sea-52362

Résumé

Mycosis fungoides (MF), the commonest variant of primary cutaneous T cell lymphoma (CTCL), is relatively uncommon among the Asians. Hypopigmented mycosis fungoides is a rare variant usually observed in dark-skinned individuals, especially children. Hypopigmented MF usually responds well to therapy, particularly to PUVA, and has a comparatively benign course. Mycosis fungoides in a 16-year-old boy, with extensive asymptomatic hypopigmented lesions developing gradually all over the body over eight years and vitiligo-like skin lesions developing for seven years, with no systemic features, is presented for its unusual clinical features and conspicuous histopathological findings of prominent epidermotropism. The case showed fairly good response to PUVASOL therapy.

15.
Indian J Exp Biol ; 2003 Jun; 41(6): 603-8
Article Dans Anglais | IMSEAR | ID: sea-61169

Résumé

Somatic karyotypes in M. tengara contained 54 chromosomes, comprising 26 homomorphic pairs in both sexes and one pair of heteromorphic nature in female (one big submetacentric and one small subtelocentric chromosomes), while in males this pair was homomorphic (with two big sub-metacentric chromosomes). The Nucleolus Organizer Regions (NORs) were located at one arm of the suspected sex elements in both sexes, while another pair of metacentric chromosomes (No.7) also showed Ag-positive arm. The CMA3 technique revealed relatively bright fluorescing zones in the regions of chromosomes that showed Ag-positive staining, revealing thereby the preponderance of GC-rich active sites of rRNA genes in NORs. SEM studies revealed clear heteromorphism to exist in the elements suspected as sex chromosomes in females.


Sujets)
Animaux , Chromomycine A3/métabolisme , Femelle , Poissons/génétique , Caryotypage , Mâle , Microscopie électronique à balayage , Organisateur nucléolaire , Nitrate d'argent
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