Résumé
OBJECTIVE: To evaluate the effect of maternal low dose aspirin ingestion in platelet function of newborn. DESIGN: Prospective randomized placebo controlled study. METHODS: 25 neonates born to mothers receiving low dose aspirin and 25 matched neonates with no maternal exposure to aspirin were studied. 2 ml of EDTA and 4.5 ml of citrate blood was collected from umbilical vein using double clamped umbilical stump for hemogram, coagulation profile and platelet functions. RESULTS: The platelet counts (10(9)/l) of study and control groups were 186.4 +/- 22.76 (116-225) and 205.28 +/- 17.34 (176-225), respectively. There was no significant difference in coagulation parameters. Prothrombin time index (PTI) was 86.24 +/- 6.623 and 87 +/- 6.43, respectively in the study and control group while PTTK (sec) was 55.88 +/- 20.54 and 52.12 +/- 11.82 in study and control subjects, respectively. The platelet aggregation studies (platelet function) with various platelet agonists in study and control group did not show any significant difference. Clinically, none of the babies had bleeding. CONCLUSIONS: Use of low dose aspirin in pregnant women was found to be safe and had no adverse effects on platelet functions of newborn.
Sujets)
Acide acétylsalicylique/usage thérapeutique , Plaquettes/effets des médicaments et des substances chimiques , Femelle , Sang foetal , Humains , Nouveau-né/sang , Antiagrégants plaquettaires/usage thérapeutique , Numération des plaquettes , Tests fonctionnels plaquettaires , Pré-éclampsie/prévention et contrôle , Grossesse , Issue de la grossesse , Études prospectives , Facteurs tempsRésumé
Neste trabalho é apresentado o projeto e desenvolvimento de um espectrofluorímetro para a obtenção de espectros de fluorescência e refletância difusa de tecidos biológicos em um tempo inferior a 1s. Para acessar a região da diagnose, o sistema utiliza um catéter a fibra óptica para excitação do tecido e captação da fluorescência emitida. O sistema é desenvolvido para aplicação em procedimentos clínicos in vivo, onde o tempo de realização do experimento é objetivo de extrema importância
Abstract- This work presents the project and development of a spectrofluorimeter in order to obtain the fluorescence spectra and diffuse reflectance from biological tissues with period of time below 1 s. The diagnose region is reached with an optical fiber catheter for tissue excitation and collection of the emitted fluorescence. This system is developed for in vivo clinicai applications, where duration of the experimental procedure is a very important parameter