RÉSUMÉ
Background: The size and location of the stone have been suggested as the most important predictors of the possibility of spontaneous passage of the stone. The aim of this study was to investigate the predictive effect of neutrophil to lymphocyte ratio as an inflammatory marker in the spontaneous excretion of ureteral stones. Methods: This descriptive-analytical study was done on 95 patients with ureteral stone during 2020-21. Required data include sex, age, BMI, previous history of stone, previous history of spontaneous passage of stone, side, location and size of stones, spontaneous passage of stone, and neutrophil and lymphocyte ratio were extracted from file of patients. The presence of the stone and its characteristics were confirmed by ultrasound. Patients were followed up for 2 weeks to determine whether or not the stone passed spontaneously. Results: There was a significant relationship between spontaneous passage of ureteral stone with stone size, location, and neutrophil to lymphocyte ratio. The cut-off points of neutrophil to lymphocyte ratio for predicting spontaneous passage of ureteral stone was 2.52, so that patients with higher values were faced with a 4.2-fold increase in the risk of no spontaneous passage of stones (OR=4.202, 95% CI: 1.563-11.298, Sig.=0.004). Conclusions: The results of the study showed that the ratio of neutrophils to lymphocytes is a significant predictor of spontaneous passage of ureteral stones, so that if used in addition to the size and location of the stone, the accuracy of predicting patients who benefit from conservative management, increase significantly.
RÉSUMÉ
Background: The size and location of the stone have been suggested as the most important predictors of the possibility of spontaneous passage of the stone. The aim of this study was to investigate the predictive effect of neutrophil to lymphocyte ratio as an inflammatory marker in the spontaneous excretion of ureteral stones. Methods: This descriptive-analytical study was done on 95 patients with ureteral stone during 2020-21. Required data include sex, age, BMI, previous history of stone, previous history of spontaneous passage of stone, side, location and size of stones, spontaneous passage of stone, and neutrophil and lymphocyte ratio were extracted from file of patients. The presence of the stone and its characteristics were confirmed by ultrasound. Patients were followed up for 2 weeks to determine whether or not the stone passed spontaneously. Results: There was a significant relationship between spontaneous passage of ureteral stone with stone size, location, and neutrophil to lymphocyte ratio. The cut-off points of neutrophil to lymphocyte ratio for predicting spontaneous passage of ureteral stone was 2.52, so that patients with higher values were faced with a 4.2-fold increase in the risk of no spontaneous passage of stones (OR=4.202, 95% CI: 1.563-11.298, Sig.=0.004). Conclusions: The results of the study showed that the ratio of neutrophils to lymphocytes is a significant predictor of spontaneous passage of ureteral stones, so that if used in addition to the size and location of the stone, the accuracy of predicting patients who benefit from conservative management, increase significantly.
RÉSUMÉ
Background: According to the recent studies on patients with stones in the urinary system, the CRP serum levels can be useful in predicting the possibility of success in expectant treatment and spontaneous excretion of stone and thus, selecting the appropriate patient for this treatment approach; however the studies conducted in this field are inadequate and the results obtained are slightly contradictory. The aim of this study was to investigate the relationship between spontaneous excretion of lower ureter stones with stone size and serum level of C-reactive protein. Methods: This cross-sectional study has been done on 95 patients with lower ureter stone during 2020-2021. Information including gender, age, body mass index, stone size, spontaneous excretion of stone, and CRP serum level were extracted from the files of patients. The existence of stone and its characteristics have been confirmed using ultrasound. Results: The mean CRP serum level was 8.74�5.06 mg/l and the frequency of spontaneous stone excretion was 72.6% (n=69). CRP serum level was significantly lower in patients with spontaneous stone excretion (7.42 vs. 12.23 mg/l and p=0.001). The cut-off point of CRP serum level was 13.5 mg/l for patients with ureter stone size of 4-7 (with 84% sensitivity and 58% specificity) and for patients with ureter stone size of 7-10, it was 12.5 mg/l (with 83% sensitivity and 56% specificity). Conclusions: The results showed that there is a significant relationship between the CRP serum levels, along with stone size with spontaneous excretion of lower ureter stones.