RÉSUMÉ
Background: Nutritional anemia, with iron-deficiency anemia as the most prevalent type, is a pressing global health concern, impacting two billion people worldwide. Among vulnerable groups, school-going adolescents aged 10 to 17 years require special attention due to the critical phase of growth and development during this period. This study aims to assess the prevalence of anemia and its association with sociodemographic factors among adolescents in Thiruvallur district, Tamil Nadu. Methods: A cross-sectional study was conducted among 900 adolescent girls, utilizing a multistage sampling technique. Hemoglobin levels were measured using one-touch blood sampling, and physical examinations were performed by trained healthcare professionals. A structured questionnaire collected sociodemographic information, dietary habits, and lifestyle factors. Results: The study revealed a concerning prevalence of anemia, with 60% of the participants affected. Among these, 41.3% experienced moderate anemia, while 18.4% had mild anemia, and 0.4% had severe anemia. A significant correlation was observed between anemia prevalence and low socio-economic status among the participants. Conclusions: The high prevalence of anemia among adolescent girls in Thiruvallur district underscores the urgency of targeted interventions and public health initiatives to address this critical health issue. Improving nutrition, healthcare access, and socio-economic conditions are crucial steps in combating anemia's impact on school-going adolescents. Collaborative efforts from policymakers, healthcare providers, and community organizations are essential in eradicating nutritional anemia and enhancing the health and prospects of adolescents in the studied region.
RÉSUMÉ
Background: Coronary artery disease (CAD) is the primary cause of death in developed countries and is one of the leading causes of disease burden in developing countries. Methods: This descriptive cross-sectional study included 124 purposively selected patients who underwent elective CAG in the department of cardiology, Chittagong medical college hospital, Chattogram, from July 2020 to June 2021. SPSS 23.0 software was used for processing and analysis at the end of the data collection period. Results: According to the Gensini score, patients were categorized into two groups (score <30 and ?30). There were no significant differences between the two groups concerning BMI, smoking, hypertension, DM, F/H of CAD, statin or beta-blocker use, or the levels of hemoglobin, hematocrit, MCV, MCH MCHC, and creatinine. However, the mean age was older, and there were more males in the severe CAD group. The percentage of dyslipidemia was significantly higher in patients with Gensini score ?30 than in patients with <30. RDW (OR: 2.629; 95% CI: 1.425-4.484; p=0.002) and age (OR: 1.058; 95%CI: 1.00-1.111; p=0.027) were independently correlated with the severity of CAD. The AUROC for red cell distribution width (RDW) was 0.915 with a p<0.001 for predicting CAD on CAG. It indicated a statistically significant association of RDW with the presence of CAD. A cut-off value of 13.65% RDW had a sensitivity of 80% and specificity of 84.2% for the prediction of CAD. There were no significant differences between patients with and without angiographic CAD for BMI, hypertension, DM, statin, or beta-blocker use, or of the levels of hemoglobin, hematocrit, MCV, MCH, MCHC, and creatinine. However, the mean age was older, and there were more males in the CAD group. The percentage with dyslipidemia, smoking, and F/H of CAD was significantly higher in patients with CAD than in patients without CAD. The data indicate that only RDW was independently correlated with the presence of CAD (OR: 2.593; 95% CI: 1.347-4.989; p=0.004). Conclusions: RDW is associated with the presence of CAD and suggests that it might be a readily available test for predicting coronary artery diseases.
RÉSUMÉ
Purpose: The purpose of the study was to analyze the correlation between central field index (CFI) and activity limitation in glaucoma using glaucoma activity limitation-9 (GAL-9) questionnaire. Methods: This hospital-based, cross-sectional, noninterventional study, included 50 patients diagnosed with glaucoma, with field defect encroaching onto central 10� in Humphrey field analysis 30�program, in at least one eye. These patients underwent central 10�field analysis and CFI was calculated with the help of a calculator created by us. Patients with severe cognitive impairment were excluded and the rest completed the GAL-9 questionnaire. The data was analyzed to determine the correlation between the CFI and the GAL-9 scores. Results: There was a moderate correlation between CFI of better eye (r = ?0.431, confidence interval 揅I� ?0.619 to ?0.173, P < 0.002) and worse eye (r = ?0.342, CI: ?0.575 to ? 0.058, P < 0.015) with GAL-9, the better eye showing a stronger correlation. Mean deviations (MD) of both better (r = ?0.345, CI: ?0.556 to ?0.069, P < 0.014) and worse eye (r = ?0.346, CI: ?0.578 to ?0.063 P < 0.014) showed similar moderate correlation. Vision of better eye (r = ?0.398, CI: ?0.577 to ?0.210, P < 0.004) showed a stronger correlation with GAL-9 score than worse eye (r = ?0.188, CI: ?0.475 to 0.100, P < 0.192). Subscales of GAL-9 questionnaire also correlated with better eye status. 揊inding dropped objects� had the strongest correlation to CFI of better eye (r = ?0.676) and 揳djusting to dim lights� had the weakest correlation (r = ?0.052). Conclusion: The better eye status in glaucoma patients correlated better than worse eye with regard to activity limitation, signifying that the better eye has a greater influence on the quality of life and how patients perceive their disability. Furthermore, CFI showed a better correlation with GAL-9 score than MD.
RÉSUMÉ
BACKGROUND: Data of febrile neutropenia (FN) from rural cancer centers is sparse. We did a audit of outcome of patients with FN in the period of March 2013‑August 2013. The aim was to help us to develop rational antibiotic usage policies. MATERIALS AND METHODS: Retrospective analysis of all consecutive patients presenting with FN. Data regarding demographic profile, tumor type, intent of treatment, chemotherapy regimen, blood culture susceptibility details, use of antibiotics, response to antibiotics and complications of FN were noted. SPSS (Statistical Product and Service Solutions) 16 was used for analysis. RESULTS: 67 patients had FN and there were 91 episodes. The median day of presentation with FN after start of chemotherapy was 10 days. The nadir absolute neutrophil count was 161.5 and nadir platelet count 1,00,000. The median multinational association for supportive care in cancer (MASCC) Score was 24. In accordance with MASCC there were 27 high risk FN and 64 low risk FN episodes. On multivariate analysis using logistic regression MASCC score strata was the only significant variable that predicted failure to 1st line antibiotics (P = 0.03) and mortality (P = 0.01). Nine patients (9.9%) had positive isolates on blood cultures. The blood culture isolates were predominantly Gram negative (66.7%). CONCLUSION: The importance of developing local guidelines for rational antibiotic usage is highlighted.
RÉSUMÉ
The expression profiles of inflammatory cytokines viz. interleukins (IL)-6, IL-8, IL-12, granulocyte macrophage-colony stimulating factor, interferon-gamma and tumor necrosis factor-alpha in response to subclinical mastitis in indigenous cattle breed Kankrej (n = 6), Gir (Bos indicus) (n = 12) and crossbred (Bos taurus x Bos indicus) (n = 7) were investigated using quantitative real time PCR. Significant correlation (p < 0.05) was observed between total bacterial load and somatic cell count (SCC) in all three breeds of cattle. All the cytokines were observed to be up-regulated compared to cows with healthy quarters, however, level of their expression varied among three breeds of cattle. In Kankrej most cytokines were found to be transcribed to higher levels than in other two breeds; the milk had higher load of bacteria but not so high SCC, implying that Kankrej has a higher inherent resistance against mastitis. The results of present study indicated that mammary glands of crossbred cattle are more sensitive to bacterial infection than indigenous breed of cattle as they elicit immune response at lower bacterial load and result into higher SCC. Research on identification of factors responsible for differentially expressed cytokines profiles and use of cytokines as immunomodulatory tools can pave way for formulating control strategies against bovine mastitis.