Résumé
Trans-anethole was studied for antifertility activity in rats at dose levels of 50 mg, 70 mg and 80 mg/kg po. Dose-dependent activity was observed, a 100% anti-implantation activity being achieved at 80 mg/kg, po. The compound showed a significant estrogenic activity and did not possess anti-estrogenic, progestational, anti-progestational, androgenic or anti-androgenic activities. In an earlier study, the compound was found to be safe, its LD50 being more than 3000 mg/kg, po in mice.
Sujets)
Avortement provoqué , Animaux , Anisoles/pharmacologie , Contraceptifs oraux/pharmacologie , Relation dose-effet des médicaments , Oestradiol/pharmacologie , Oestrogènes/administration et posologie , Femelle , Fécondité/effets des médicaments et des substances chimiques , Dose létale 50 , Mâle , Taille d'organe/effets des médicaments et des substances chimiques , Ovariectomie , Grossesse , Prostate/effets des médicaments et des substances chimiques , Rats , Vésicules séminales/effets des médicaments et des substances chimiques , Testostérone/pharmacologieRésumé
Potassium embelate, 2,5-dihydroxy, 3-undecyl-1, 4-benzoquinone, from Embelia ribes Burm. was subjected to toxicity evaluation which included subacute, chronic, reproductive toxicity testing and teratological investigations in laboratory animals (mice, rats and monkeys). The results did not indicate adverse effects suggesting that potassium embelate is a safe compound.