Résumé
OBJECTIVE: To probe into the incidence rate of ADR and safety of influenza A H1N1 vaccine. METHODS: 228 of medical staff of our hospital was vaccinated influenza A H1N1 vaccine on Nov. 24th in 2009 and followed up at the following day. 36 cases ADR were collected and statistically analyzed in respects of gender, age, the classification of ADR, organs or system involved and clinical manifestation, prognosis of ADR. RESULTS: The incidence rate of ADR was 15.79% versus 14.52% in the instruction. ADR were mostly occurred in nervous system (42.86%). Of 5 persons in same department, ADR occurred in four persons whose vaccines were kept at constant temperature for five hours; ADR didn’t occurred in only one person who were vaccinated in time. Incidence rate of ADR were 16.33% for female and 14.81% for male. Severe ADR accounted for 0.44% of total ADR and all cases were cured and improved. Of 36 ADR cases, severe ADR appeared in one of six patients who had allergic history. CONCLUSION: The influenza A H1N1 vaccine should be strictly used and stored according to drug instruction. People who are hypersensitive to drugs should be vaccinated carefully and observed closely after vaccination. Most of vaccination is safe although some slight and short-term ADR will appear.