Countermeasure and status quo of the training of General Practice teachers in the mainland of China / 中华医学教育探索杂志

Strengthening the construction of teaching staff is the urgent need for ensuring the quality of education in General Practice (GP), cultivating high-quality talents as well as promoting the comprehensive and healthy development of the GP education. According to the analysis of current do-mestic and foreign teachers, the comparison of teachers' training mode and drawing lessons from for-eign experience of cultivating teachers, the suitable training mode of Chinese situation was explored, putting forward the thinking of the culture and construction of general medicine teachers by deepening the reform of medical education and the comprehensive reform of the medical and health system.

Clinical efficacy of neoadjuvant chemotherapy with platinum-based regimen for patients with locoregionally advanced head and neck squamous cell carcinoma: an evidence-based meta-analysis

As a vital chemotherapeutic modality, the clinical benefits of neoadjuvant chemotherapy still remain uncertain and controversial. The purpose of this meta-analysis was to evaluate the efficacy of neoadjuvant chemotherapy with a platinum-based regimen for patients with locoregional stage III or IV squamous cell carcinoma of the head and neck. Meta-analysis of randomized, controlled trials. Relevant randomized controlled trials [RCTs] were identified through systematic search and selected according to the inclusion and exclusion criteria. Eligible RCTs were further analyzed by systematic meta-analysis. Statistical analysis was performed by Review Manager 5.0.21.0 software. A total of 6 RCTs were identified. Pooling effects revealed that there was no statistical significance in locoregional recurrence [relative risk [RR]= 1.06; 95% Cl [confidence interval= 0.91-1.24; P>.05], distant metastasis [RR= 0.6; 95% Cl= 0.28-1.30; P>.05], disease-free survival [RR= 0.93; 95% Cl= 0.75-1.15; P>.05] or overall survival [RR= 0.98; 95% Cl= 0.89-1.09; P>.05]. More of the common hematological adverse effects were reported with a cisplatin-based regimen. All the studies analyzed in this meta-analysis were individual RCTs with adequate follow-up and relatively narrow confidence intervals, which were classified to the 1 b level, and this meta-analysis was classified to the 1 a level, according to the Levels of Evidence [March 2009] of Oxford Center for Evidence-based Medicine. The meta-analysis indicates there is a non-significant difference between neoadjuvant chemotherapeutic treatment and conventional locoregional modality for patients at high risk of recurrence, with regard to overall survival, disease-free survival, distant metastases, and locoregional recurrence. However, well-performed studies of identical platinum-based combinations as neoadjuvant chemotherapeutic regimen are needed for further evaluation