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Objective To analyze the blood of patients with hepatitis B cirrhosis complicated with iron deficiency anemia(IDA).Methods The 100 cases with hepatitis B cirrhosis complicated with IDA and hepatitis B cirrhosis complicated with non-iron deficiency anemia (NIDA) were recruited in our hospital from December 2013 to May 2015,and were divided into observation group (50 cases) and control group(50 cases) according to whether complicated with IDA.The liver function,blood routine,liver cirrhosis patients with coagulation test and measurement of the platelet parameters of two groups of patients were detected and analyzed.Results After treatment,no statistically significant difference were observed the levels of albumin,bilirubin,bile acid and alkaline phosphatase between two groups (P>0.05).The levels of alanine amino transferase (ALT),gamma glutamyltransferase (GGT) in the observation group were significantly higher than those in the control group(P0.05).The prothrombin time (PT),International normalized ratio (INR),activated partial thromboplastin time (APTT),thrombin time (TT) of observation group were higher than the control group(P0.05).Conclusion The detection of blood in patients with hepatitis B cirrhosis complicated with IDA is of great significance in the evaluation of the degree of liver damage and the diagnosis of the disease,which is worthy of clinical application in the future.
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Objective To evaluate the feasibility of the DNA microarray method used in detecting the drug resistance of Myco-bacterium tuberculosis by comparing the traditional proportion method and the DNA microarray method for detecting the drug re-sistance of Mycobacterium tuberculosis.Methods 54 strains of Mycobacterium tuberculosis isolated from clinical specimens in our hospital from January 2012 to March 2013 were randomly extracted and their resistance to isonicotinic acid hydrazide (INH)and rifampicin(RFP)was detected by the DNA microarray method and the proportion method.The detection results were performed the comparative analysis.Results With the proportion method as the golden standard,the coincidence rates of the DNA microarray method for detecting the Mycobacterium tuberculosis resistance to INH and RFP were 75% and 91.0% respectively.Conclusion The DNA microarray technique is suitable for the rapid screening of clinical first-line drug resistant Mycobacterium tuberculosis.
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Objective To evaluate the electrophysiological change in patients with acute tetrodotoxin(TTX) poisoning.Methods The electromyogram, motor nerve conduction velocity(MCV), sensory nerve conduction velocity(SCV),F wave,H reflex and somatosensory evoked potentials(SEP) were randomly detected in 58 patients with acute TTX poisoning.Results 22 patients with TTX(37.9%) detected by the electromyogram showed mainly polyphase irregular waves;MCV and SCV were weakened; SCV was even more remarkable,the latency of distant MCV action potentials was prolonged obviously, the abnormality rate of nerve conduction velocity was much higher than that of fibrillation,the detectable rats of positive wave was high,the low abnormality rate of F wave and H reflex suggested that the ill TTX poisoning involved the nerve roots;the abnormality rate of SEP was 56.9%.Conclusion TTX poisoning can company with the damage of central nerves, the measure of electroneurophysiology can be used to observe the extent,course and range of nerve system damage in patients with acute TTX poisoning, and it is one of the early detection means of this disease.
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OBJECTIVE: To determine the efficacy and safety of early intervention with nimodipine treatment in diffuse axonal injury. METHODS: Based on the characteristic radiological signs and criteria for diffuse axonal injury (DAI), 89 patients with the diagnosis of DAI were enrolled in this randomized, double-blind, placebo-controlled trial. RESULTS: Nimodipine proved to be safe and well tolerated. With TCD sonography we found that there was a higher incidence of cerebral vasospasm in this series (38.2%). Overall, Nimodipine produced a better clinical result than placebo, but there was no statistically significant difference in favorable outcome at 3 months after injury (P=0.11) between the two groups. A trend toward a favorable effect was suggested by the analyses in two small subgroups, either in the patients suffering from clinical Grade III DAI (P=0.04), or in those with the TCD-evidence of cerebral vasospasm during clinical observation (P=0.049). CONCLUSIONS: We postulate that a clinically valuable benefit is possible with nimodipine treatment in DAI patients. However, the effects on outcome should be verified by further controlled study.