Three new bioactive flavonoid glycosides from Viscum album / 中国天然药物

Two new flavonoid glycosides, named viscumneoside XII (1), and viscumneoside XIII (2); a new dihydrogen flavonoid glycoside product named viscumneoside XIV (3), were isolated from the aerial part of Viscum album, along with seven known compounds (4-10). Their structures were identified by analysis of spectroscopic data. In addition, cytotoxicity assay showed that 1, 2 and 3 possessed significant inhibitory activities against C6, A549 and MDA-MB-231 (the inhibition rate arrived about 50%, 70% and 74% respectively with IC ≤ 60.00 μmol·L), while the inhibition of TF-1 and Hela was not significant.

Two symmetrical unsaturated acids isolated from Viscum album / 中国天然药物

In the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 - 11). Their structures were confirmed on the basis of spectroscopic data. Compounds 1 and 8 showed antioxidant activity against xanthine oxidase (XOD) and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydroxyl (DPPH), with the IC of 1.22 and 1.33 μmol·L, and the SC of 4.34 and 8.22 μmol·L, respectively.

Research on chemical constituents from branches and twigs with leaves of Viscum coloratum / 中草药

Objective: To study the chemical constituents from the dry stem leaves parts of Viscum coloratum. Methods: The chemical constituents were separated and purified by various column chromatographies and HPLC. Their structures were determined on the basis of spectroscopic analyses (1H-NMR, 13C-NMR, 2D-NMR, and MS). The dry stem leaves of V. coloratum were extracted by 95% ethanol, then concentrated and was extracted by water and chloroform. Then the water part was eluted by the gradient of water and ethanol (100:0→0:100), obtaining the six parts of water, 10% ethanol, 30% ethanol, 50% ethanol, 70% ethanol, and 95% ethanol. Results: Nine compounds were isolated from the 50% EtOH extract in the dry stem leaves parts of V. coloratum with the structures identified as rhamnazin-3-O-β-D-api (1→2)-O-β-D-glucoside (1), rhamnazine (2), rhamnazin-3-O-β-D-glucoside (3), rhamnazin-3- O-β-D-(6″-acetyl)-O-β-D-glucoside (4), homeriodictyol-7-O-β-D-glucoside (5), homeriodictyol-7-O-β-D-api (1→2)-O-β-D-glucoside (6), homeriodictyol-7-O-β-D- glucoside-4'-O-β-D-apioside (7), homeriodictyol-7-O-β-D-glucosid (8), and liquidamboside (9). Conclusion: Compound 1 is a new flavonoid glycoside, named as viscumneoside IX, and the compound 9 is isolated from the dry stem leaves parts of V. coloratumi first time.

Research progress on chemical constituents in plants from Viscum L. and their pharmacological activities / 中草药

Visci Herba used as traditional Chinese materia medica has a long history. Flavonoids, triterpenoids, phenylpropanoids and so on are the main chemical constituents in Visci Herba. The study shows that Visci Herba has a wide range of pharmacological activities, such as antineoplastic, antineoplastic, hyperglycemic effect, anti-microbial, anti-aging, antioxidant, antiplatelet aggregation, anti-thrombus formation, and improving minicirculation. In this paper, through arrenging the domestic and foreign relevant literatures on Visci Herba systematacially, the chemical constituents from Visci Herba and their pharmacological activities are reviewed, which could provide the reference for the further investigation and development of this plant.

Comparison of the efficacy and safety of compound carraghenates cream and compound carraghenates suppository in the treatment of mixed hemorrhoids / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To evaluate and compare the efficacy and safety of titanoreine cream with compound carraghenates suppository in the treatment of mixed hemorrhoids.</p><p><b>METHODS</b>Two hundred and fifty-two patients with mixed hemorrhoids were enrolled in this randomized,open, multicentral trial. Patients applied titanoreine cream (study group, n=133) or compound carraghenates suppository (control group, n=119). The symptomatic relief including pain,bleeding and edema was evaluated by scoring system at 30 minutes, 3 hours, 6 hours, 1 day, 2 days, 3 days, 4 days, 6 days after administration.</p><p><b>RESULTS</b>Symptoms were significantly improved in both groups (87.3%, 94.8%, respectively) excepting symptom of pain relief, but there was no significant difference between two groups (P > 0.05). The pain scores were lower at every observing point in the study group than those in the control group (P< 0.05). The proportions of the patients with pain relief and all symptoms relief were both higher in the study group than that in the control group at 30 min, 3 h after drug used (both P< 0.01). No side effect was found during the triad.</p><p><b>CONCLUSION</b>Titanoreine cream has predominance of relieving pain and response time compared with compound carraghenates suppository, but other effects on mixed hemorrhoid are similar between the two groups.</p>