Effect of etoricoxib on experimental oxidative testicular ischemia-reperfusion damage in rats induced with torsion-detorsion

Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular I/R damage induced with torsion-detorsion (TD). The etoricoxib + torsion-detorsion (ETD) groups of animals were given etoricoxib in 50 and 100 mg/kg of body weight (ETD-50 and ETD-100), while the testes torsion-detorsion (TTD) and sham operation rat group (SOG) animals were given single oral doses of distilled water as a solvent. TTD, ETD-50 and ETD-100 groups were subjected to 720° degrees torsion for four hours, and detorsion for four hours. The SOG group was not subjected to this procedure. Biochemical, gene expression and histopathological analyses were carried out on the testicular tissues. The levels of malondialdehyde (MDA), myeloperoxidase (MPO), interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) were significantly higher, and the levels of total glutathione (tGSH) and glutathione reductase (GSHRd) were significantly lower in the TTD group, compared to the ETD-50, ETD-100 and SOG groups. Etoricoxib at a dose of 100 mg/kg better prevented I/R damage than the 50 mg/kg dose. Etoricoxib may be useful in clinical practice in the reduction of I/R damage on testes caused by torsion-detorsion.

Effect of infliximab against cisplatin-induced nephrotoxicity

To investigate whether infliximab [Ib], an inhibitor of tumor necrosis factor alpha [TNF-alpja], prevents cisplatin [Cis] -induced nephrotoxicity. The study was performed in the Department of Internal Medicine, RecepTayyip Erdogan University, Rize, Turkey, between November 2012 and May 2013. Thirty male Wistar albino rats were divided into 3 groups, a control group, a Cis group, and a Cis+Ib group. The animals of the Cis group were injected with a single dose [7 mg/kg] of Cis intraperitoneally. The animals of the Cis+Ib group were injected with a single dose [7 mg/kg] of Ib 72 hours prior to Cis injection. The TNF-a, interleukin-1 beta [IL-1J3], nitric oxide [NO] and adenosine deaminase [ADA] levels of the Cis group were higher than both the control group TNF-alpha [p<0.001], IL-la [p<0.001], NO [p<0.001] and ADA [p<0.001], and the Cis+Ib group TNF-alpha [p<0.001], IL-1[3 [p<0.001], NO [p<0.001], and ADA [f=0.003]. Histopathological examination revealed extensive damage in the Cis group, while the damage in the Cis+Ib group was lower. While the carbonic anhydrase II [CA-II] level of the Cis group was lower than both groups, it was similar in the Cis+Ib and the control groups. Infliximab acts against Cis-induced nephrotoxicity by a strong inhibition of TNF-alpha. Additionally, the combination of these 2 drugs does not obviously change the level of CA-II