Résumé
Rheumatoid arthritis [RA] is a multifactorial disorder related to the inflammatory response system with debilitating and painful conditions. Both genetic and environmental factors, with unknown etiology, play important roles in this disease pathogenesis. Recently, TRAF1/C5 [Tumor Necrosis Factor Receptor-Associated Factor 1/Complement Component 5] polymorphism associated with increased risk for RA has been studied in different populations worldwide, and inconsistent results have been obtained, rs 10818488 allele is located on TRAF1/C5 intergenic region, and has been predicted to be functional. A total of 100 sex- and age-matched people including RA patients [n = 50] and healthy individuals [n = 50] from Iran have been entered in this study and genotyped for rs 10818488 [A/G] polymorphism, using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism [PCR-RFLP]. In our study, rs10818488 allele was not associated with risk for RA in Iranian population [p > 0.05, OR = 1.27, 95% CI = 0.72-2.23]. Results revealed that this allele might be population-specific and not to be associated with their corresponding gene pool. However, further analyses are required to clarify other RA-associated markers in our community