Résumé
We investigated the changes in and the correlations between serum oxidized low density lipoproteins [OX-LDL], iron, ferritin, uric acid and albumin in children and adolescents had autoimmune hepatitis [AIH], a chronic liver disease. Patients group had higher activities of serum transaminases and higher level of serum total bilirubin than normal values. Also, all of them gave positive results for antismooth muscle antibody test. In addition, results revealed that the concentration of oxidized low density lipoproteins antibodies [OX-LDL Ab] a marker for OX-LDL concent-ration in patients was significantly increased [P =/< 0.001] when compared with that of healthy controls. Moreover, serum ferritin, iron, and uric acid levels showed higher values in patients with different significant levels [P =/< 0.001, 0.025 and 0.001] respectively from those of the control subjects. Correlation study demonstrated that patients serum ferritin level had significant positive correlation with serum uric acid [r 0.406, p =/< 0.05]. Also, a positive correlation was found between serum uric acid and albumin [r 0.428, P =/< 0.05]. In healthy control group, a positive correlation [r 0.671, P =/< 0.05] was found between serum uric acid and albumin. Patients suffered from AIH for =/< 5 years showed significant increase in each of serum iron, ferritin, uric acid levels [P =/< 0.001] and in OX-LDL-Ab concentration [P =/< 0.05] as compared with those of control group. Furthermore, in other patients group [AIH for =/> 5 years], serum OX-LDL ab, ferritin and uric acid levels significantly increased [P =/< 0.001,0.005 and 0.001 respectively] as compared with those of the controls. On the other hand, comparison of these parameters between both groups of patients showed no significant changes. In conclusion, OX-LDL and ferritin increased in all patients regardless the duration of the disease. Increase the intake of natural antioxidants and decrease the intake of iron are recommended for those patients