The Stimulatory Effect of Intragastric Administration of Crude Aqueous Extract of Ageratum Conyzoides on Gastric Acid Secretion in Rats

The effect of an aqueous leaf of Ageratum conyzoides on gastric acid secretion in rats was investigated in 18 albino rats of Wistar strain. The rats were divided into 2 groups of 9 each. Gastric acid output was determined by continuous perfusion in urethane anaesthetized rats. Control gastric acid output was obtained usign 0.9

Inhibitory effect of manganese on contraction of isolated rat aorta.

The effects of MnCl2 on vascular smooth muscle contraction induced by noradrenaline (NA) and KCl were investigated. Rings segments from rat aorta were isolated and changes in isometric tension recorded. MnCl2 (10 microM and 1 mM) significantly attenuated the contractile responses to NA and KCI. There were also reductions in the contractile responses to CaCl2 in NA- and KCl-stimulated rings, after pretreatment with MnCl2. The magnitude of the phasic contraction to NA was significantly reduced in presence of MnCl2. The results suggest that MnCl2 inhibits vascular smooth muscle contraction by influencing a Ca2+-mediated mechanism.